Malaysian and Chinese King Cobra Venom Cytotoxicity in Melanoma and Neonatal Foreskin Fibroblasts Is Mediated by Age and Geography

• Published in: Toxins Vol. 15; no. 9; p. 549
• Main Authors: Op den Brouw, Bianca, Fernandez-Rojo, Manuel A, Charlton, Tom, Fry, Bryan G, Ikonomopoulou, Maria P
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 01.09.2023; MDPI
• Subjects: Adults; Age; Age composition; animal venom; Anticancer properties; Biocompatibility; Biotechnology; Cancer; Captive breeding; Care and treatment; Cells; cobra snakes; Cytotoxicity; Drug development; Evolution; Females; Fibroblasts; Geographical distribution; Geographical locations; Geography; Habitats; Hatching; Heterogeneity; Influence; Juveniles; Melanoma; Morphology; Neonates; Neurotoxicity; Ontogeny; Ophiophagus hannah; Physiological aspects; Populations; Predators; Prey; Snakes; Toxicity; Toxins; Venom; Venom toxins; Australia; Malaysia

Snake venoms constitute a complex, rapidly evolving trait, whose composition varies between and within populations depending on geographical location, age and preys (diets). These factors have determined the adaptive evolution for predatory success and link venom heterogeneity with prey specificity....