CD47 expression regulated by the miR-133a tumor suppressor is a novel prognostic marker in esophageal squamous cell carcinoma

• Published in: Oncology reports Vol. 28; no. 2; pp. 465 - 472
• Main Authors: SUZUKI, SHIGEMASA, YOKOBORI, TAKEHIKO, TANAKA, NARITAKA, SAKAI, MAKOTO, SANO, AKIHIKO, INOSE, TAKANORI, SOHDA, MAKOTO, NAKAJIMA, MASANOBU, MIYAZAKI, TATSUYA, KATO, HIROYUKI, KUWANO, HIROYUKI
• Format: Journal Article
• Language: English
• Published: Athens D.A. Spandidos 01.08.2012; Spandidos; Spandidos Publications UK Ltd
• Subjects: Aged; Animals; Biological and medical sciences; Biomarkers; Biomarkers, Tumor - biosynthesis; Biomarkers, Tumor - genetics; Bladder cancer; Carcinoma, Squamous Cell - genetics; Carcinoma, Squamous Cell - metabolism; CD47; CD47 Antigen - biosynthesis; CD47 Antigen - genetics; Cell Growth Processes - genetics; Cell Line, Tumor; Esophageal cancer; Esophageal Neoplasms - genetics; Esophageal Neoplasms - metabolism; Esophageal Squamous Cell Carcinoma; Esophagus; Female; Females; Gastroenterology. Liver. Pancreas. Abdomen; Gene expression; Gene Expression Profiling; Genes, Tumor Suppressor; Humans; Leukemia; Lymphatic system; Male; Medical prognosis; Medical sciences; Metastasis; Mice; Mice, Inbred BALB C; Mice, Nude; MicroRNAs - genetics; MicroRNAs - metabolism; Middle Aged; miR-133a; Multivariate analysis; Prognosis; Squamous cell carcinoma; Transfection; Transplantation, Heterologous; Tumors; Xenograft Model Antitumor Assays; Prognosis; esophageal cancer; Esophageal disease; Esophagus squamous cell carcinoma; Biological marker; Malignant tumor; miR-133a; Esophagus cancer; Cancerology; Integrin associated protein; Digestive diseases; CD47; Cancer; Tumor suppressor gene

CD47 inhibits phagocytosis and its overexpression is correlated with poor prognosis in patients with several types of cancer. It has also been reported that CD47 expression in multiple sclerosis is regulated by microRNAs. However, the regulatory mechanism of CD47 in cancer tissues has not been yet c...