Assessment of Grouped Weighted Quantile Sum Regression for Modeling Chemical Mixtures and Cancer Risk

• Published in: International journal of environmental research and public health Vol. 18; no. 2; p. 504
• Main Authors: Wheeler, David C., Rustom, Salem, Carli, Matthew, Whitehead, Todd P., Ward, Mary H., Metayer, Catherine
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 09.01.2021; MDPI
• Subjects: Cancer; Case-Control Studies; Chemicals; Child; Computer Simulation; Environmental Exposure - analysis; Generalized linear models; Humans; Lagrange multiplier; Leukemia; Neoplasms - chemically induced; Neoplasms - epidemiology; PCB; Polychlorinated biphenyls; Regularization methods; Research Design; Risk Assessment; Risk Factors; United States > US; California; environment; cancer; chemicals; mixtures

Individuals are exposed to a large number of diverse environmental chemicals simultaneously and the evaluation of multiple chemical exposures is important for identifying cancer risk factors. The measurement of a large number of chemicals (the exposome) in epidemiologic studies is allowing for a mor...