Cytotoxicity Produced by Silicate Nanoplatelets: Study of Cell Death Mechanisms

• Published in: Toxins Vol. 12; no. 10; p. 623
• Main Authors: Huang, Jie-Ting, Chang, Ling-Chu, Cheng, Chung-Ssu, Lin, Jiang-Jen, Huang, San-Yuan, Chen, Shuen-Ei
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 29.09.2020; MDPI
• Subjects: Apoptosis; Apoptosis-inducing factor; Caspase-6; Caspase-8; Cell death; Cytochrome c; Cytochromes; Cytotoxicity; Endocytosis; Fluorescence; Integrity; Internalization; Kinases; membrane integrity; Membranes; Mitochondria; Mortality; Mycotoxicosis; NADH; NADH oxidase; nano-silicate platelets; Necroptosis; Necrosis; Nicotinamide adenine dinucleotide; Oral administration; Permeability; Platelets (materials); Proteins; Reactive oxygen species; Toxicity; Translocation; endocytosis; membrane integrity; nano-silicate platelets; reactive oxygen species; necroptosis

Nano-silicate platelets (NSP), an exfoliated product from natural clays, have been validated for biosafety and as an effective supplement to alleviate mycotoxicosis. Since NSP induced noticeable cell death, we therefore investigated further the mechanism of cytotoxicity caused by NSP. Exposure to NS...