Imiquimod Enhances IFN-γ Production and Effector Function of T Cells Infiltrating Human Squamous Cell Carcinomas of the Skin

• Published in: Journal of investigative dermatology Vol. 129; no. 11; pp. 2676 - 2685
• Main Authors: Huang, Susan J., Hijnen, Dirkjan, Murphy, George F., Kupper, Thomas S., Calarese, Adam W., Mollet, Ilse G., Schanbacher, Carl F., Miller, Danielle M., Schmults, Chrysalyne D., Clark, Rachael A.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.11.2009; Nature Publishing Group
• Subjects: Aminoquinolines - pharmacology; Antineoplastic Agents - pharmacology; Apoptosis - drug effects; Apoptosis - immunology; Biological and medical sciences; Biopsy; Carcinoma, Squamous Cell - drug therapy; Carcinoma, Squamous Cell - immunology; Carcinoma, Squamous Cell - pathology; CD8-Positive T-Lymphocytes - drug effects; CD8-Positive T-Lymphocytes - immunology; CD8-Positive T-Lymphocytes - metabolism; Cell Division - drug effects; Cell Division - immunology; Dermatology; Granzymes - metabolism; Humans; In Vitro Techniques; Interferon-gamma - metabolism; Interleukin-10 - metabolism; Lymphocyte Activation - drug effects; Lymphocyte Activation - immunology; Medical sciences; Perforin; Pore Forming Cytotoxic Proteins - metabolism; Signal Transduction - drug effects; Signal Transduction - immunology; Skin Neoplasms - drug therapy; Skin Neoplasms - immunology; Skin Neoplasms - pathology; Transforming Growth Factor beta - metabolism; Tumors of the skin and soft tissue. Premalignant lesions; Human; Immunomodulator; Skin disease; Squamous cell carcinoma; Basal cell carcinoma; Dermatology; Imiquimod; T-Lymphocyte; Antiviral; Skin; Malignant tumor; Cancer

Squamous cell carcinomas (SCCs) are sun-induced skin cancers that are particularly numerous and aggressive in patients taking T-cell immunosuppressant medications. Imiquimod is a topical immune response modifier and Toll-like receptor 7 (TLR7) agonist that induces the immunological destruction of SC...