Downregulation of Membrane Trafficking Proteins and Lactate Conditioning Determine Loss of Dendritic Cell Function in Lung Cancer

• Published in: Cancer research (Chicago, Ill.) Vol. 78; no. 7; pp. 1685 - 1699
• Main Authors: Caronni, Nicoletta, Simoncello, Francesca, Stafetta, Francesca, Guarnaccia, Corrado, Ruiz-Moreno, Juan Sebastian, Opitz, Bastian, Galli, Thierry, Proux-Gillardeaux, Veronique, Benvenuti, Federica
• Format: Journal Article
• Language: English
• Published: United States American Association for Cancer Research, Inc 01.04.2018; American Association for Cancer Research
• Subjects: Animals; Antigen (tumor-associated); Antigen presentation; Antigen Presentation - immunology; Antigens; Antigens, Neoplasm - immunology; Antitumor activity; Cancer; CD8 antigen; CD8-Positive T-Lymphocytes - immunology; Cell Line, Tumor; Cellular Biology; Culture Media, Conditioned - metabolism; Dendritic cells; Dendritic Cells - immunology; Down-Regulation; Endosomes; Endosomes - metabolism; Immunology; Immunotherapy; Interferon; Interferon Type I - antagonists & inhibitors; Interleukin 1; Interleukin 12; Lactic acid; Lactic Acid - metabolism; Life Sciences; Lung cancer; Lung Neoplasms - immunology; Lung Neoplasms - pathology; Lymphocytes T; Membrane trafficking; Membrane Transport Proteins - biosynthesis; Mice; Mice, Inbred C57BL; Mice, Knockout; Protein transport; SNAP receptors; SNARE Proteins - biosynthesis; T cell receptors; TLR3 protein; Toll-like receptors; Tumor Microenvironment - immunology; Tumors; Vesicle-Associated Membrane Protein 3 - biosynthesis; Membrane Trafficking; Lactate; Lung; Dendritic Cell; Cancer; SNARE; VAMP3

Restoring antigen presentation for efficient and durable activation of tumor-specific CD8+ T-cell responses is pivotal to immunotherapy, yet the mechanisms that cause subversion of dendritic cell (DC) functions are not entirely understood, limiting the development of targeted approaches. In this stu...