The effects of omega-3 fatty acids monotherapy in Alzheimer's disease and mild cognitive impairment: A preliminary randomized double-blind placebo-controlled study

• Published in: Progress in neuro-psychopharmacology & biological psychiatry Vol. 32; no. 6; pp. 1538 - 1544
• Main Authors: Chiu, Chih-Chiang, Su, Kuan-Pin, Cheng, Tsung-Chi, Liu, Hsing-Cheng, Chang, Ching-Jui, Dewey, Michael E., Stewart, Robert, Huang, Shih-Yi
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Inc 01.08.2008; Elsevier
• Subjects: Adult and adolescent clinical studies; Aged; Aged, 80 and over; Alzheimer Disease - blood; Alzheimer Disease - drug therapy; Alzheimer Disease - psychology; Alzheimer’s disease; Biological and medical sciences; Cognition; Cognition Disorders - blood; Cognition Disorders - drug therapy; Cognition Disorders - psychology; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Double-Blind Method; Eicosapentaenoic Acid - therapeutic use; Erythrocyte Membrane - chemistry; Erythrocyte Membrane - drug effects; Fatty Acids, Omega-3 - adverse effects; Fatty Acids, Omega-3 - therapeutic use; Fatty Acids, Unsaturated - blood; Female; Fish oil; Geriatrics; Humans; Male; Medical sciences; Mild cognitive impairment; Neurology; Neuropharmacology; Neuropsychological Tests; Olea; Organic mental disorders. Neuropsychology; Pharmacology. Drug treatments; Polyunsaturated fatty acids; Psychiatric Status Rating Scales; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Treatment Outcome; AA; AD; Alzheimer’s disease; ADAS-cog; CIBIC-plus; Mild cognitive impairment; Polyunsaturated fatty acids; Cognition; Fish oil; MCI; LA; ALA; MMSE; EPA; DHA; HDRS; PUFAs; Nervous system diseases; Cognitive disorder; Alzheimer disease; Polyunsaturated fatty acid; Lipids; n-3 fatty acid; Cerebral disorder; Randomization; Central nervous system disease; Placebo; Double blind study; Unsaturated fatty acid; Degenerative disease; mild cognitive impairment; Alzheimer's disease
• ISSN: 0278-5846; 1878-4216
• DOI: 10.1016/j.pnpbp.2008.05.015

A 24-week, randomized, double-blind placebo-controlled study was carried out to test the feasibility of using omega-3 polyunsaturated fatty acids (PUFAs) monotherapy in people with cognitive impairment and to explore its effects on cognitive function and general clinical condition in these participa...