TGF-β activation by bone marrow-derived thrombospondin-1 causes Schistosoma- and hypoxia-induced pulmonary hypertension

• Published in: Nature communications Vol. 8; no. 1; pp. 15494 - 13
• Main Authors: Kumar, Rahul, Mickael, Claudia, Kassa, Biruk, Gebreab, Liya, Robinson, Jeffrey C., Koyanagi, Daniel E., Sanders, Linda, Barthel, Lea, Meadows, Christina, Fox, Daniel, Irwin, David, Li, Min, McKeon, B. Alexandre, Riddle, Suzette, Dale Brown, R., Morgan, Leslie E., Evans, Christopher M., Hernandez-Saavedra, Daniel, Bandeira, Angela, Maloney, James P., Bull, Todd M., Janssen, William J., Stenmark, Kurt R., Tuder, Rubin M., Graham, Brian B.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 30.05.2017; Nature Publishing Group; Nature Portfolio
• Subjects: 13/31; 13/51; 38/77; 631/250/256/2516; 64/110; 64/60; 692/699/1785; Animals; Antigens, Ly - metabolism; Basic Helix-Loop-Helix Transcription Factors - metabolism; Bone Marrow Cells - metabolism; Cattle; Humanities and Social Sciences; Humans; Hypertension, Pulmonary - etiology; Hypertension, Pulmonary - genetics; Hypertension, Pulmonary - immunology; Hypertension, Pulmonary - parasitology; Hypoxia - complications; Hypoxia - pathology; Lung - blood supply; Lung - metabolism; Lung - pathology; Mice, Inbred C57BL; Monocytes - metabolism; multidisciplinary; RNA, Messenger - genetics; RNA, Messenger - metabolism; Schistosoma - physiology; Science; Science (multidisciplinary); Signal Transduction; Th2 Cells - immunology; Thrombospondin 1 - blood; Thrombospondin 1 - genetics; Thrombospondin 1 - metabolism; Transforming Growth Factor beta - metabolism

Pulmonary arterial hypertension (PAH) is an obstructive disease of the precapillary pulmonary arteries. Schistosomiasis-associated PAH shares altered vascular TGF-β signalling with idiopathic, heritable and autoimmune-associated etiologies; moreover, TGF-β blockade can prevent experimental pulmonary...