Pharmaceutical Assessment Suggests Locomotion Hyperactivity in Zebrafish Triggered by Arecoline Might Be Associated with Multiple Muscarinic Acetylcholine Receptors Activation

• Published in: Toxins Vol. 13; no. 4; p. 259
• Main Authors: Siregar, Petrus, Audira, Gilbert, Feng, Ling-Yi, Lee, Jia-Hau, Santoso, Fiorency, Yu, Wen-Hao, Lai, Yu-Heng, Li, Jih-Heng, Lin, Ying-Ting, Chen, Jung-Ren, Hsiao, Chung-Der
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 03.04.2021; MDPI
• Subjects: Acetylcholine receptors (muscarinic); Animal behavior; arecoline; betel nut; Danio rerio; Drug dosages; Embryos; Ethanol; Experiments; Exposure; Fertilization; Growth rate; Hyperactivity; Larvae; Ligands; Light; Locomotion; Locomotor activity; Molecular docking; Molecular structure; Morphology; muscarinic acetylcholine receptor; Nicotinic acid; Oral cancer; Phenotypes; Receptors; Side effects; Simulation; Zebrafish; betel nut; molecular docking; locomotion; muscarinic acetylcholine receptor; zebrafish; arecoline; antagonist

Arecoline is one of the nicotinic acid-based alkaloids, which is found in the betel nut. In addition to its function as a muscarinic agonist, arecoline exhibits several adverse effects, such as inducing growth retardation and causing developmental defects in animal embryos, including zebrafish, chic...