FADS Polymorphisms Affect the Clinical and Biochemical Phenotypes of Metabolic Syndrome

• Published in: Metabolites Vol. 12; no. 6; p. 568
• Main Authors: Žák, Aleš, Jáchymová, Marie, Burda, Michal, Staňková, Barbora, Zeman, Miroslav, Slabý, Adolf, Vecka, Marek, Šeda, Ondřej
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 20.06.2022; MDPI
• Subjects: Acute coronary syndromes; Alzheimer's disease; Blood pressure; Body fat; Body weight; Cardiovascular disease; Cluster analysis; Coronary vessels; Desaturase; Discriminant analysis; Enzymes; FADS1; fatty acid pattern; Fatty acids; Gene expression; Genetic factors; Genotype & phenotype; Glucose; Haplotypes; High density lipoprotein; Homeostasis; Hypertension; Inflammation; Insulin resistance; Lipolysis; Metabolic syndrome; Obesity; Oxidative stress; Patients; Phenotypes; Plasma; Polymorphism; Polyunsaturated fatty acids; single-nucleotide polymorphism; Statistical analysis; Stroke; Vein & artery diseases; metabolic syndrome; FADS2; haplotypes; cluster analysis; single-nucleotide polymorphism; FADS1; fatty acid pattern

Long-chain polyunsaturated fatty acids (LC-PUFAs) play important roles in human health, from controlling inflammation to lipid and glucose homeostasis. In our previous study, which employed a cluster analysis of a plasma fatty acid (FA) pattern, we identified two clusters of metabolic syndrome (MetS...