cJun promotes CNS axon growth

• Published in: Molecular and cellular neuroscience Vol. 59; pp. 97 - 105
• Main Authors: Lerch, Jessica K., Martínez-Ondaro, Yania R., Bixby, John L., Lemmon, Vance P.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.03.2014
• Subjects: Animals; Antigens, CD - genetics; Antigens, CD - metabolism; Axon; Axons - metabolism; Axons - physiology; Cells, Cultured; Cerebral Cortex - cytology; Cerebral Cortex - growth & development; Cerebral Cortex - metabolism; cJun; Cortical neuron; GAP-43 Protein - genetics; GAP-43 Protein - metabolism; Gene Expression Regulation, Developmental; HEK293 Cells; Humans; Integrin alpha Chains - genetics; Integrin alpha Chains - metabolism; Nerve Regeneration; Neurogenesis; Oncogene Protein p65(gag-jun) - genetics; Oncogene Protein p65(gag-jun) - metabolism; Rats; Rats, Sprague-Dawley; Regeneration; STAT6 Transcription Factor - genetics; STAT6 Transcription Factor - metabolism; Transcription factor; JUN; PTEN; Axon; KLFs; Oxr1; cJun; SOCS3; Regeneration; GAP43; TF; Cortical neuron; CGNs; BHLHE40; DRG; ITGA7; Transcription factor; PN

A number of genes regulate regeneration of peripheral axons, but their ability to drive axon growth and regeneration in the central nervous system (CNS) remains largely untested. To address this question we overexpressed eight transcription factors and one small GTPase alone and in pairwise combinat...