Altered distribution of mGlu2 receptors in β-amyloid-affected brain regions of Alzheimer cases and aged PS2APP mice

• Published in: Brain research Vol. 1363; pp. 180 - 190
• Main Authors: Richards, Grayson, Messer, Jürg, Faull, Richard L.M, Stadler, Heinz, Wichmann, Jürgen, Huguenin, Philipp, Bohrmann, Bernd, Mutel, Vincent
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 06.12.2010; Elsevier
• Subjects: Adult and adolescent clinical studies; Aged; Aged, 80 and over; Aging; Aging - metabolism; Aging - pathology; Alzheimer Disease - metabolism; Alzheimer Disease - pathology; Alzheimer's disease; Amyloid beta-Peptides - metabolism; Amyloid beta-Peptides - pharmacology; Amyloidosis; Animals; Biological and medical sciences; Bridged Bicyclo Compounds - metabolism; Bridged Bicyclo Compounds - pharmacology; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Excitatory Amino Acid Agonists - metabolism; Excitatory Amino Acid Agonists - pharmacology; Hippocampus; Hippocampus - metabolism; Hippocampus - pathology; Humans; In vitro binding; Iodine Radioisotopes; LY354740; Male; Medical sciences; Metabotropic glutamate receptor; mGlu2; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Transgenic; Neurology; Organic mental disorders. Neuropsychology; Peptide Fragments - metabolism; Peptide Fragments - pharmacology; Perforant path; Presenilin-2 - genetics; Presenilin-2 - metabolism; PS2APP double transgenic mouse; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Quantitative receptor radioautography; Radioligand Assay; Rats; Rats, Inbred F344; Receptor agonist; Receptors, Metabotropic Glutamate - metabolism; Tritium; LY354740; secondary visual cortex, lateral area; Receptor agonist; DG; M1; M2; entorhinal cortex; SIDZ; PS2APP double transgenic mouse; primary somatosensory cortex, barrel field; CA1; S; primary somatosensory cortex; CA3; primary somatosensory cortex, dysgranular region; SI; Aging; lacunosum moleculare; AID; Alzheimer's disease; EC; molecular layer dentate gyrus; Metabotropic glutamate receptor; primary motor cortex; Quantitative receptor radioautography; Perforant path; cornu ammonis region 3; agranular insular cortex, ventral part; caudate putamen; In vitro binding; agranular insular cortex, dorsal part; CPu; subiculum; Mol; substantia innominata; presubiculum; AIV; mGlu2; PrS; V2L; dentate gyrus; secondary motor cortex; Amyloidosis; SIBF; LMol; S1; Hippocampus; cornu ammonis region 1; Agonist; Senescence; Alzheimer disease; Central nervous system; Transgenic animal; Glutamate receptor; Enzymopathy; Encephalon; Degenerative disease; Biological receptor; Nervous system diseases; Rodentia; Metabolic diseases; In vitro; mglu2 glutamate receptor; Cerebral disorder; Vertebrata; Mammalia; Metabotropic receptor; Mouse; β Amyloid protein; Central nervous system disease; Distribution

Abstract Altered glutamatergic synaptic transmission is among the key events defining the course of Alzheimer's disease (AD). mGlu2 receptors, a subtype of group II metabotropic glutamate receptors, regulate (as autoreceptors) fast synaptic transmission in the CNS via the controlled release of...