Scalable control of mounting and attack by Esr1+ neurons in the ventromedial hypothalamus

• Published in: Nature (London) Vol. 509; no. 7502; pp. 627 - 632
• Main Authors: Lee, Hyosang, Kim, Dong-Wook, Remedios, Ryan, Anthony, Todd E., Chang, Angela, Madisen, Linda, Zeng, Hongkui, Anderson, David J.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 29.05.2014
• Subjects: 13/1; 14/19; 42/41; 631/378; 64/60; 9/74; Aggression - physiology; Animals; Estrogen Receptor alpha - metabolism; Female; Humanities and Social Sciences; Integrases - genetics; Integrases - metabolism; letter; Male; Mice; multidisciplinary; Neurons - metabolism; Optogenetics; Science; Sexual Behavior, Animal - physiology; Ventromedial Hypothalamic Nucleus - cytology; Ventromedial Hypothalamic Nucleus - physiology

Activation of Esr1 + neurons of the mouse ventromedial hypothalamus initiates graded social behavioural responses–weak activation triggers close investigation (sniffing) during a social encounter that often leads, with continued stimulation, to mounting behaviours by males towards either gender; mou...