Integrated metabolomic and transcriptomic analysis reveals perturbed glycerophospholipid metabolism in mouse neural stem cells exposed to cadmium

• Published in: Ecotoxicology and environmental safety Vol. 264; p. 115411
• Main Authors: Li, Yixi, Zhang, Jiming, Zhang, Yuwei, Zhang, Bing, Wang, Zheng, Wu, Chunhua, Zhou, Zhijun, Chang, Xiuli
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01.10.2023; Elsevier
• Subjects: arginine; biochemical pathways; biosynthesis; Cadmium; cell proliferation; dicarboxylic acids; ecotoxicology; gene expression regulation; Glycerophospholipid; glycerophospholipids; heavy metals; metabolites; Metabolomic; metabolomics; mice; mitochondria; multiomics; Neural stem cell; neurotoxicity; Phosphatidylethanolamine; proline; signal transduction; Transcriptomic; transcriptomics; Metabolomic; Cadmium; Phosphatidylethanolamine; Transcriptomic; Glycerophospholipid; Neural stem cell

Cadmium (Cd) is a ubiquitous heavy metal with neurotoxicity. Our previous study reported that Cd could inhibit the proliferation of mouse neural stem cells (mNSCs). However, the underlying mechanisms are obscure. In recent years, the rapid growth of multi-omics techniques enables us to explore the c...