The search for a PKR code—differential regulation of protein kinase R activity by diverse RNA and protein regulators

• Published in: RNA (Cambridge) Vol. 25; no. 5; pp. 539 - 556
• Main Authors: Bou-Nader, Charles, Gordon, Jackson M., Henderson, Frances E., Zhang, Jinwei
• Format: Journal Article
• Language: English
• Published: United States Cold Spring Harbor Laboratory Press 01.05.2019
• Subjects: Allosteric properties; Allosteric Regulation; Animals; Base Sequence; Binding Sites; Cell survival; Cellular stress response; Double-stranded RNA; eIF-2 kinase; eIF-2 Kinase - chemistry; eIF-2 Kinase - genetics; eIF-2 Kinase - immunology; Gene Expression Regulation; Host-Pathogen Interactions - genetics; Host-Pathogen Interactions - immunology; Humans; Immunity, Innate; Innate immunity; Interferon; Interferon-inducible protein; Interferons - genetics; Interferons - immunology; Kinases; Protein Binding; Protein Interaction Domains and Motifs; Protein kinase R; Protein Structure, Secondary; Proteins; Review; RNA, Double-Stranded - chemistry; RNA, Double-Stranded - genetics; RNA, Double-Stranded - immunology; RNA, Untranslated - chemistry; RNA, Untranslated - genetics; RNA, Untranslated - immunology; Structure-function relationships; Virus Diseases - genetics; Virus Diseases - immunology; Virus Diseases - virology; Virus Replication; noncoding RNA; allosteric regulation; innate immunity; antiviral defense; PKR

The interferon-inducible protein kinase R (PKR) is a key component of host innate immunity that restricts viral replication and propagation. As one of the four eIF2α kinases that sense diverse stresses and direct the integrated stress response (ISR) crucial for cell survival and proliferation, PKR&#...