Multi-platform mass spectrometry analysis of the CSF and plasma metabolomes of rigorously matched amyotrophic lateral sclerosis, Parkinson's disease and control subjects

• Published in: Molecular bioSystems Vol. 12; no. 4; pp. 1287 - 1298
• Main Authors: Wuolikainen, Anna, Jonsson, Pär, Ahnlund, Maria, Antti, Henrik, Marklund, Stefan L, Moritz, Thomas, Forsgren, Lars, Andersen, Peter M, Trupp, Miles
• Format: Journal Article
• Language: English
• Published: England 01.01.2016
• Subjects: Amyotrophic Lateral Sclerosis - blood; Amyotrophic Lateral Sclerosis - cerebrospinal fluid; Biomarkers; Case-Control Studies; Female; Humans; Male; Mass Spectrometry - methods; Metabolome; Metabolomics - methods; Neurosciences; Neurovetenskaper; Parkinson Disease - blood; Parkinson Disease - cerebrospinal fluid; Reproducibility of Results

Amyotrophic lateral sclerosis (ALS) and Parkinson's disease (PD) are protein-aggregation diseases that lack clear molecular etiologies. Biomarkers could aid in diagnosis, prognosis, planning of care, drug target identification and stratification of patients into clinical trials. We sought to ch...