Ameliorative Effect of Annona muricata (Graviola) Extract on Hyperglycemia Induced Hepatic Damage in Type 2 Diabetic Mice

• Published in: Antioxidants Vol. 10; no. 10; p. 1546
• Main Authors: Son, Yiseul, Lee, Heaji, Son, Su-Young, Lee, Choong-Hwan, Kim, Sun-Yeou, Lim, Yunsook
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 29.09.2021; MDPI
• Subjects: AMPK/Akt-mTOR signaling; Annona muricata; Autophagy; Diabetes; Diabetes mellitus; Diet; Energy metabolism; Experiments; Fatty acids; Glucose; Glucose metabolism; Glucose transporter; hepatic lipid steatosis; High fat diet; Homeostasis; Hyperglycemia; Insulin; Insulin receptor substrate 1; Insulin resistance; Kinases; Lipid metabolism; Lipids; lipophagy; Liver; Metabolism; non-alcoholic fatty liver disease (NAFLD); Oxidation; Oxidative stress; Peroxisome proliferator-activated receptors; Phagocytosis; Streptozocin; TOR protein; type 2 diabetes mellitus (T2DM); United States > US; non-alcoholic fatty liver disease (NAFLD); hepatic lipid steatosis; AMPK/Akt-mTOR signaling; autophagy; lipophagy; Annona muricata; graviola; type 2 diabetes mellitus (T2DM)

(AM) is evergreen plant of the family and known to have anticancer and antidiabetic effects. However, anti-diabetic mechanisms of AM extracts (AME) associated with hepatic glucose regulation and lipid metabolism remain unclear. In this study, we investigated the protective effect of AME extracted on...