Dietary supplementation of vitamin D prevents the development of western diet-induced metabolic, hepatic and cardiovascular abnormalities in rats
Background The western diet high in fat and fructose may cause metabolic disorders and cardiovascular diseases. Objective To evaluate whether long-term daily vitamin D3 supplementation prevents hepatic steatosis and cardiovascular abnormalities and restores insulin sensitivity caused by fat diet in...
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| Published in | United European gastroenterology journal Vol. 6; no. 7; pp. 1056 - 1064 |
|---|---|
| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
London, England
SAGE Publications
01.08.2018
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Background
The western diet high in fat and fructose may cause metabolic disorders and cardiovascular diseases.
Objective
To evaluate whether long-term daily vitamin D3 supplementation prevents hepatic steatosis and cardiovascular abnormalities and restores insulin sensitivity caused by fat diet in rats without vitamin D deficiency.
Methods
Three groups of rats were fed for 6 months with standard diet (SD), western diet (WD) or WD containing 23 IU/day/rat vitamin D3, respectively. Tail-cuff systolic blood pressure (SBP)measurements in conscious rats and transthoracic echocardiography were performed in basal condition, and after 3 and 6 months of diet. Hepatic steatosis and myocardial fibrosis were assessed in liver and cardiac tissues using standard methods. Serum insulin and 25(OH)D3 concentrations were determined using rat-specific ELISA kits. Insulin resistance was determined according to the homeostasis model assessment of insulin resistance (HOMA-IR) method.
Results
Sixty-one per cent of hepatocytes in WD rats had steatotic vacuoles compared with just 27% in rats on a WD plus vitamin D3 (p < 0.05).HOMA-IR was reduced in rats with vitamin D supplementation compared with WD alone (19.4 ± 5.2 vs 41.9 ± 8.9, p < 0.05). Rat blood pressure and left ventricular mass were both reduced by vitamin D3 supplementation.
Conclusion
In animal models of liver and cardiovascular metabolic damage, the supplementation of vitamin D3 shows liver and cardio-protective effects. |
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| AbstractList | Background
The western diet high in fat and fructose may cause metabolic disorders and cardiovascular diseases.
Objective
To evaluate whether long-term daily vitamin D3 supplementation prevents hepatic steatosis and cardiovascular abnormalities and restores insulin sensitivity caused by fat diet in rats without vitamin D deficiency.
Methods
Three groups of rats were fed for 6 months with standard diet (SD), western diet (WD) or WD containing 23 IU/day/rat vitamin D3, respectively. Tail-cuff systolic blood pressure (SBP)measurements in conscious rats and transthoracic echocardiography were performed in basal condition, and after 3 and 6 months of diet. Hepatic steatosis and myocardial fibrosis were assessed in liver and cardiac tissues using standard methods. Serum insulin and 25(OH)D3 concentrations were determined using rat-specific ELISA kits. Insulin resistance was determined according to the homeostasis model assessment of insulin resistance (HOMA-IR) method.
Results
Sixty-one per cent of hepatocytes in WD rats had steatotic vacuoles compared with just 27% in rats on a WD plus vitamin D3 (p < 0.05).HOMA-IR was reduced in rats with vitamin D supplementation compared with WD alone (19.4 ± 5.2 vs 41.9 ± 8.9, p < 0.05). Rat blood pressure and left ventricular mass were both reduced by vitamin D3 supplementation.
Conclusion
In animal models of liver and cardiovascular metabolic damage, the supplementation of vitamin D3 shows liver and cardio-protective effects. The western diet high in fat and fructose may cause metabolic disorders and cardiovascular diseases.BACKGROUNDThe western diet high in fat and fructose may cause metabolic disorders and cardiovascular diseases.To evaluate whether long-term daily vitamin D3 supplementation prevents hepatic steatosis and cardiovascular abnormalities and restores insulin sensitivity caused by fat diet in rats without vitamin D deficiency.OBJECTIVETo evaluate whether long-term daily vitamin D3 supplementation prevents hepatic steatosis and cardiovascular abnormalities and restores insulin sensitivity caused by fat diet in rats without vitamin D deficiency.Three groups of rats were fed for 6 months with standard diet (SD), western diet (WD) or WD containing 23 IU/day/rat vitamin D3, respectively. Tail-cuff systolic blood pressure (SBP)measurements in conscious rats and transthoracic echocardiography were performed in basal condition, and after 3 and 6 months of diet. Hepatic steatosis and myocardial fibrosis were assessed in liver and cardiac tissues using standard methods. Serum insulin and 25(OH)D3 concentrations were determined using rat-specific ELISA kits. Insulin resistance was determined according to the homeostasis model assessment of insulin resistance (HOMA-IR) method.METHODSThree groups of rats were fed for 6 months with standard diet (SD), western diet (WD) or WD containing 23 IU/day/rat vitamin D3, respectively. Tail-cuff systolic blood pressure (SBP)measurements in conscious rats and transthoracic echocardiography were performed in basal condition, and after 3 and 6 months of diet. Hepatic steatosis and myocardial fibrosis were assessed in liver and cardiac tissues using standard methods. Serum insulin and 25(OH)D3 concentrations were determined using rat-specific ELISA kits. Insulin resistance was determined according to the homeostasis model assessment of insulin resistance (HOMA-IR) method.Sixty-one per cent of hepatocytes in WD rats had steatotic vacuoles compared with just 27% in rats on a WD plus vitamin D3 (p < 0.05).HOMA-IR was reduced in rats with vitamin D supplementation compared with WD alone (19.4 ± 5.2 vs 41.9 ± 8.9, p < 0.05). Rat blood pressure and left ventricular mass were both reduced by vitamin D3 supplementation.RESULTSSixty-one per cent of hepatocytes in WD rats had steatotic vacuoles compared with just 27% in rats on a WD plus vitamin D3 (p < 0.05).HOMA-IR was reduced in rats with vitamin D supplementation compared with WD alone (19.4 ± 5.2 vs 41.9 ± 8.9, p < 0.05). Rat blood pressure and left ventricular mass were both reduced by vitamin D3 supplementation.In animal models of liver and cardiovascular metabolic damage, the supplementation of vitamin D3 shows liver and cardio-protective effects.CONCLUSIONIn animal models of liver and cardiovascular metabolic damage, the supplementation of vitamin D3 shows liver and cardio-protective effects. The western diet high in fat and fructose may cause metabolic disorders and cardiovascular diseases. To evaluate whether long-term daily vitamin D supplementation prevents hepatic steatosis and cardiovascular abnormalities and restores insulin sensitivity caused by fat diet in rats without vitamin D deficiency. Three groups of rats were fed for 6 months with standard diet (SD), western diet (WD) or WD containing 23 IU/day/rat vitamin D , respectively. Tail-cuff systolic blood pressure (SBP)measurements in conscious rats and transthoracic echocardiography were performed in basal condition, and after 3 and 6 months of diet. Hepatic steatosis and myocardial fibrosis were assessed in liver and cardiac tissues using standard methods. Serum insulin and 25(OH)D3 concentrations were determined using rat-specific ELISA kits. Insulin resistance was determined according to the homeostasis model assessment of insulin resistance (HOMA-IR) method. Sixty-one per cent of hepatocytes in WD rats had steatotic vacuoles compared with just 27% in rats on a WD plus vitamin D ( < 0.05).HOMA-IR was reduced in rats with vitamin D supplementation compared with WD alone (19.4 ± 5.2 vs 41.9 ± 8.9, < 0.05). Rat blood pressure and left ventricular mass were both reduced by vitamin D supplementation. In animal models of liver and cardiovascular metabolic damage, the supplementation of vitamin D shows liver and cardio-protective effects. |
| Author | D’Armiento, Maria D’Argenio, Giuseppe Morisco, Carmine Caporaso, Nicola Lembo, Vincenzo Giudice, Carmine Del Mazzone, Giovanna Rossi, Antonella Trimarco, Bruno Morisco, Filomena |
| AuthorAffiliation | 2 Department of Advanced Biomedical Sciences, University ‘Federico II’, Naples, Italy 1 Gastroenterology, Department of Clinical Medicine and Surgery, University ‘Federico II’, Naples, Italy |
| AuthorAffiliation_xml | – name: 2 Department of Advanced Biomedical Sciences, University ‘Federico II’, Naples, Italy – name: 1 Gastroenterology, Department of Clinical Medicine and Surgery, University ‘Federico II’, Naples, Italy |
| Author_xml | – sequence: 1 givenname: Giovanna surname: Mazzone fullname: Mazzone, Giovanna – sequence: 2 givenname: Carmine surname: Morisco fullname: Morisco, Carmine – sequence: 3 givenname: Vincenzo surname: Lembo fullname: Lembo, Vincenzo – sequence: 4 givenname: Giuseppe orcidid: 0000-0002-7217-0960 surname: D’Argenio fullname: D’Argenio, Giuseppe – sequence: 5 givenname: Maria surname: D’Armiento fullname: D’Armiento, Maria – sequence: 6 givenname: Antonella surname: Rossi fullname: Rossi, Antonella – sequence: 7 givenname: Carmine Del surname: Giudice fullname: Giudice, Carmine Del – sequence: 8 givenname: Bruno orcidid: 0000-0002-0701-6449 surname: Trimarco fullname: Trimarco, Bruno – sequence: 9 givenname: Nicola surname: Caporaso fullname: Caporaso, Nicola email: nicola.caporaso@unina.it – sequence: 10 givenname: Filomena surname: Morisco fullname: Morisco, Filomena |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30228894$$D View this record in MEDLINE/PubMed |
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The western diet high in fat and fructose may cause metabolic disorders and cardiovascular diseases.
Objective
To evaluate whether long-term daily... Background The western diet high in fat and fructose may cause metabolic disorders and cardiovascular diseases. Objective To evaluate whether long‐term daily... The western diet high in fat and fructose may cause metabolic disorders and cardiovascular diseases. To evaluate whether long-term daily vitamin D... The western diet high in fat and fructose may cause metabolic disorders and cardiovascular diseases.BACKGROUNDThe western diet high in fat and fructose may... |
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| SubjectTerms | cardiovascular disease Diabetes HOMA insulin Original vitamin D western diet |
| Title | Dietary supplementation of vitamin D prevents the development of western diet-induced metabolic, hepatic and cardiovascular abnormalities in rats |
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