Mitochondrial dysfunction and cell senescence: deciphering a complex relationship

• Published in: FEBS letters Vol. 593; no. 13; pp. 1566 - 1579
• Main Authors: Chapman, James, Fielder, Edward, Passos, João F.
• Format: Journal Article
• Language: English
• Published: England 01.07.2019
• Subjects: ageing; Aging - pathology; Animals; cell senescence; Cellular Senescence; Humans; metabolites; mitochondria; Mitochondria - pathology; Phenotype; reactive oxygen species; senescence; senolytics; senostatics; therapeutics; senescence; senolytics; ageing; mitochondria; senostatics

Cellular senescence and mitochondrial dysfunction have both been defined as classical hallmarks of the ageing process. Here, we review the intricate relationship between the two. In the context of ageing, it is now well regarded that cellular senescence is a key driver in both ageing and the onset o...