G Protein‐Coupled receptors and heterotrimeric G proteins as cancer drivers

• Published in: FEBS letters Vol. 594; no. 24; pp. 4201 - 4232
• Main Authors: Arang, Nadia, Gutkind, J. Silvio
• Format: Journal Article
• Language: English
• Published: England 01.12.2020
• Subjects: angiogenesis; cancer; cancer metabolism; Carcinogenesis; Disease Progression; drug resistance; G protein‐coupled receptors; GTPases; Heterotrimeric GTP-Binding Proteins - metabolism; Humans; immune evasion; immune therapy; inflammation; landscapes; metastasis; morbidity; mortality; neoplasms; Neoplasms - metabolism; Neoplasms - pathology; precision medicine; Receptors, G-Protein-Coupled - metabolism; Signal Transduction; therapeutics; cancer metabolism; immune therapy; G protein-coupled receptors; GTPases; inflammation; metastasis; signal transduction; angiogenesis; precision medicine; cancer

G protein‐coupled receptors (GPCRs) and heterotrimeric G proteins play central roles in a diverse array of cellular processes. As such, dysregulation of GPCRs and their coupled heterotrimeric G proteins can dramatically alter the signalling landscape and functional state of a cell. Consistent with t...