G Protein‐Coupled receptors and heterotrimeric G proteins as cancer drivers

G protein‐coupled receptors (GPCRs) and heterotrimeric G proteins play central roles in a diverse array of cellular processes. As such, dysregulation of GPCRs and their coupled heterotrimeric G proteins can dramatically alter the signalling landscape and functional state of a cell. Consistent with t...

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Bibliographic Details
Published inFEBS letters Vol. 594; no. 24; pp. 4201 - 4232
Main Authors Arang, Nadia, Gutkind, J. Silvio
Format Journal Article
LanguageEnglish
Published England 01.12.2020
Subjects
angiogenesis
cancer
cancer metabolism
Carcinogenesis
Disease Progression
drug resistance
G protein‐coupled receptors
GTPases
Heterotrimeric GTP-Binding Proteins - metabolism
Humans
immune evasion
immune therapy
inflammation
landscapes
metastasis
morbidity
mortality
neoplasms
Neoplasms - metabolism
Neoplasms - pathology
precision medicine
Receptors, G-Protein-Coupled - metabolism
Signal Transduction
therapeutics
cancer metabolism
immune therapy
G protein-coupled receptors
GTPases
inflammation
metastasis
signal transduction
angiogenesis
precision medicine
cancer
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Abstract G protein‐coupled receptors (GPCRs) and heterotrimeric G proteins play central roles in a diverse array of cellular processes. As such, dysregulation of GPCRs and their coupled heterotrimeric G proteins can dramatically alter the signalling landscape and functional state of a cell. Consistent with their fundamental physiological functions, GPCRs and their effector heterotrimeric G proteins are implicated in some of the most prevalent human diseases, including a complex disease such as cancer that causes significant morbidity and mortality worldwide. GPCR/G protein‐mediated signalling impacts oncogenesis at multiple levels by regulating tumour angiogenesis, immune evasion, metastasis, and drug resistance. Here, we summarize the growing body of research on GPCRs and their effector heterotrimeric G proteins as drivers of cancer initiation and progression, and as emerging antitumoural therapeutic targets.
AbstractList G protein‐coupled receptors (GPCRs) and heterotrimeric G proteins play central roles in a diverse array of cellular processes. As such, dysregulation of GPCRs and their coupled heterotrimeric G proteins can dramatically alter the signalling landscape and functional state of a cell. Consistent with their fundamental physiological functions, GPCRs and their effector heterotrimeric G proteins are implicated in some of the most prevalent human diseases, including a complex disease such as cancer that causes significant morbidity and mortality worldwide. GPCR/G protein‐mediated signalling impacts oncogenesis at multiple levels by regulating tumour angiogenesis, immune evasion, metastasis, and drug resistance. Here, we summarize the growing body of research on GPCRs and their effector heterotrimeric G proteins as drivers of cancer initiation and progression, and as emerging antitumoural therapeutic targets.
G protein-coupled receptors (GPCRs) and heterotrimeric G proteins play central roles in a diverse array of cellular processes. As such, dysregulation of GPCRs and their coupled heterotrimeric G proteins can dramatically alter the signalling landscape and functional state of a cell. Consistent with their fundamental physiological functions, GPCRs and their effector heterotrimeric G proteins are implicated in some of the most prevalent human diseases, including a complex disease such as cancer that causes significant morbidity and mortality worldwide. GPCR/G protein-mediated signalling impacts oncogenesis at multiple levels by regulating tumour angiogenesis, immune evasion, metastasis, and drug resistance. Here, we summarize the growing body of research on GPCRs and their effector heterotrimeric G proteins as drivers of cancer initiation and progression, and as emerging antitumoural therapeutic targets.G protein-coupled receptors (GPCRs) and heterotrimeric G proteins play central roles in a diverse array of cellular processes. As such, dysregulation of GPCRs and their coupled heterotrimeric G proteins can dramatically alter the signalling landscape and functional state of a cell. Consistent with their fundamental physiological functions, GPCRs and their effector heterotrimeric G proteins are implicated in some of the most prevalent human diseases, including a complex disease such as cancer that causes significant morbidity and mortality worldwide. GPCR/G protein-mediated signalling impacts oncogenesis at multiple levels by regulating tumour angiogenesis, immune evasion, metastasis, and drug resistance. Here, we summarize the growing body of research on GPCRs and their effector heterotrimeric G proteins as drivers of cancer initiation and progression, and as emerging antitumoural therapeutic targets.
Author Arang, Nadia
Gutkind, J. Silvio
Author_xml – sequence: 1
  givenname: Nadia
  orcidid: 0000-0002-8167-2188
  surname: Arang
  fullname: Arang, Nadia
  organization: University of California, San Diego
– sequence: 2
  givenname: J. Silvio
  orcidid: 0000-0002-5150-4482
  surname: Gutkind
  fullname: Gutkind, J. Silvio
  email: sgutkind@ucsd.edu
  organization: University of California, San Diego
BackLink https://www.ncbi.nlm.nih.gov/pubmed/33270228$$D View this record in MEDLINE/PubMed
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Keywords cancer metabolism
immune therapy
G protein-coupled receptors
GTPases
inflammation
metastasis
signal transduction
angiogenesis
precision medicine
cancer
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Snippet G protein‐coupled receptors (GPCRs) and heterotrimeric G proteins play central roles in a diverse array of cellular processes. As such, dysregulation of GPCRs...
G protein-coupled receptors (GPCRs) and heterotrimeric G proteins play central roles in a diverse array of cellular processes. As such, dysregulation of GPCRs...
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SubjectTerms angiogenesis
cancer
cancer metabolism
Carcinogenesis
Disease Progression
drug resistance
G protein‐coupled receptors
GTPases
Heterotrimeric GTP-Binding Proteins - metabolism
Humans
immune evasion
immune therapy
inflammation
landscapes
metastasis
morbidity
mortality
neoplasms
Neoplasms - metabolism
Neoplasms - pathology
precision medicine
Receptors, G-Protein-Coupled - metabolism
Signal Transduction
therapeutics
Title G Protein‐Coupled receptors and heterotrimeric G proteins as cancer drivers
URI https://onlinelibrary.wiley.com/doi/abs/10.1002%2F1873-3468.14017
https://www.ncbi.nlm.nih.gov/pubmed/33270228
https://www.proquest.com/docview/2466772701
https://www.proquest.com/docview/2718339192
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