Comparison of single vs. multiple administrations of the AMPA receptors modulator S 18986 in the object recognition task in rats

• Published in: Fundamental & clinical pharmacology Vol. 21; no. 4; pp. 349 - 354
• Main Authors: Bertaina-Anglade, V., Drieu la Rochelle, C., Muñoz, C., Morain, P., Bernard, K.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.08.2007; Blackwell
• Subjects: Allosteric Regulation; AMPA modulator; Animals; Benzothiadiazines - administration & dosage; Benzothiadiazines - pharmacology; Biological and medical sciences; cognitive enhancer; Dose-Response Relationship, Drug; Drug Administration Schedule; Exploratory Behavior - drug effects; Male; Medical sciences; Memory - drug effects; Nootropic Agents - administration & dosage; Nootropic Agents - pharmacology; object recognition task; Pharmacology. Drug treatments; Psychomotor Performance - drug effects; Rats; Rats, Sprague-Dawley; Receptors, AMPA - drug effects; S 18986; Time Factors; Modulator; Rat; Rodentia; Cognition; Glutamate receptor; S 18986; Multiple dose; Vertebrata; AMPA receptor; Mammalia; Animal; AMPA modulator; object recognition task; Comparative study; cognitive enhancer

The present study aimed at defining the best scheme of administration of the α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid (AMPA) receptor‐positive modulator (S)‐2,3‐dihydro‐[3,4]‐cyclopentano‐1,2,4‐benzothiadiazine‐1,1‐dioxide (S 18986) [once daily (o.d.) administration of 1 mg/kg for 3 days...