Mitochondrial dynamics in health and disease

• Published in: FEBS letters Vol. 595; no. 8; pp. 1184 - 1204
• Main Authors: Yapa, Nethmi M.B., Lisnyak, Valerie, Reljic, Boris, Ryan, Michael T.
• Format: Journal Article
• Language: English
• Published: England 01.04.2021
• Subjects: atrophy; biogenesis; cytoskeleton; membrane dynamics; mitochondria; mitochondrial disease; mitochondrial DNA; mitochondrial fission; mitochondrial fusion; neurodegenerative diseases; organelles; oxidative phosphorylation; quality control; mitochondria; mitochondrial fission; organelles; mitochondrial fusion; membrane dynamics; mitochondrial disease; oxidative phosphorylation

In animals, mitochondria are mainly organised into an interconnected tubular network extending across the cell along a cytoskeletal scaffold. Mitochondrial fission and fusion, as well as distribution along cytoskeletal tracks, are counterbalancing mechanisms acting in concert to maintain a mitochond...