Pharmacokinetic-pharmacodynamic modeling in drug development: application to the investigational opioid trefentanil

• Published in: Clinical pharmacology and therapeutics Vol. 56; no. 3; p. 261
• Main Authors: Lemmens, H J, Dyck, J B, Shafer, S L, Stanski, D R
• Format: Journal Article
• Language: English
• Published: United States 01.09.1994
• Subjects: Adult; Alfentanil - pharmacokinetics; Analgesics - administration & dosage; Analgesics - pharmacokinetics; Analgesics - pharmacology; Computer Simulation; Drugs, Investigational - administration & dosage; Drugs, Investigational - pharmacokinetics; Drugs, Investigational - pharmacology; Electroencephalography - drug effects; Fentanyl - pharmacokinetics; Humans; Infusions, Intravenous; Male; Piperidines - administration & dosage; Piperidines - pharmacokinetics; Piperidines - pharmacology; Reference Values; Tetrazoles - administration & dosage; Tetrazoles - pharmacokinetics; Tetrazoles - pharmacology

We determined the possible benefits of a new opioid, trefentanil, relative to fentanyl and alfentanil using high-resolution pharmacokinetic-pharmacodynamic modeling and computer simulations of clinical dosing scenarios. First, we determined in nine volunteers the electroencephalographic (EEG) effect...