Mast Cell Infiltration Is Associated With Persistent Symptoms and Endoscopic Abnormalities Despite Resolution of Eosinophilia in Pediatric Eosinophilic Esophagitis

• Published in: The American journal of gastroenterology Vol. 115; no. 2; pp. 224 - 233
• Main Authors: Bolton, Scott M., Kagalwalla, Amir F., Arva, Nicoleta C., Wang, Ming-Yu, Amsden, Katie, Melin-Aldana, Hector, Dellon, Evan S., Bryce, Paul J., Wershil, Barry K., Wechsler, Joshua B.
• Format: Journal Article
• Language: English
• Published: United States Wolters Kluwer 01.02.2020; Wolters Kluwer Health Medical Research, Lippincott Williams & Wilkins
• Subjects: Adolescent; Adrenal Cortex Hormones - therapeutic use; Autoimmune diseases; Biopsy; Blood diseases; Child; Child, Preschool; Children & youth; Demographics; Diet Therapy - methods; Disease; Edema; Edema - pathology; Endoscopy; Eosinophilic Esophagitis - pathology; Eosinophilic Esophagitis - physiopathology; Eosinophilic Esophagitis - therapy; Eosinophils - pathology; Esophageal diseases; Esophagoscopy; Esophagus; Exudates and Transudates; Female; Gastroenterology; Gastroesophageal reflux; Gastrointestinal diseases; Humans; Male; Mast Cells - pathology; Patients; Pediatrics; Statistical analysis; Steroids

Mast cells (MCs) are increased in eosinophilic esophagitis (EoE). Endoscopic abnormalities, symptoms, and epithelial changes can persist after treatment despite a reduction of esophageal eosinophilia. It is unknown whether this could be due to persistent MC infiltration. We aimed to determine whethe...