The antioxidant and pro-oxidant activity of vitamin C and trolox in vitro: a comparative study

• Published in: Journal of applied toxicology Vol. 28; no. 2; pp. 183 - 188
• Main Authors: Poljšak, Borut, Raspor, Peter
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.03.2008; Wiley
• Subjects: Antioxidants - chemistry; ascorbic acid; Ascorbic Acid - chemistry; Biological and medical sciences; Chromans - chemistry; Chromium - chemistry; DNA Damage; DNA, Superhelical - chemistry; Hydrogen Peroxide - chemistry; Hydroxyl Radical - chemistry; Medical sciences; Oxidants - chemistry; Oxidation-Reduction; oxidative stress; Plasmids - chemistry; reactive oxygen species; Toxicology; Trolox; Oxidative stress; Reactive oxygen species; Ascorbic acid; DNA damage; Vitamin; α-Tocopherol; Oxidant; Antioxidant; In vitro; Biological activity; Free radical; Trolox; Analog; Lesion; Damage; Comparative study

The antioxidant and pro‐oxidant properties of ascorbic acid (vitamin C) and the water‐soluble analogue of α‐tocopherol (trolox) were compared. Trolox has advantages over α‐tocopherol, the latter being only lipid‐soluble due to the presence of a carboxyl group in lieu of a phytol chain which imparts...