Role of mitochondrial ROS in the brain: from physiology to neurodegeneration

• Published in: FEBS letters Vol. 592; no. 5; pp. 692 - 702
• Main Authors: Angelova, Plamena R., Abramov, Andrey Y.
• Format: Journal Article
• Language: English
• Published: England 01.03.2018
• Subjects: Animals; antioxidant activity; astrocytes; brain; Brain - metabolism; Brain - pathology; Cell Death; electron transport chain; energy; Energy Metabolism; homeostasis; Humans; hydrogen peroxide; mitochondria; Mitochondria - metabolism; Mitochondria - pathology; neurodegeneration; neurodegenerative diseases; Neurodegenerative Diseases - metabolism; Neurodegenerative Diseases - pathology; neuron; neurons; oxidative stress; reactive oxygen species; Reactive Oxygen Species - metabolism; superoxide anion; neurodegeneration; neuron; astrocytes; mitochondria; reactive oxygen species

Mitochondria are key cell organelles in that they are responsible for energy production and control many processes from signalling to cell death. The function of the mitochondrial electron transport chain is coupled with the production of reactive oxygen species (ROS) in the form of superoxide anion...