The role of mitochondrial ROS in the aging brain

• Published in: FEBS letters Vol. 592; no. 5; pp. 743 - 758
• Main Authors: Stefanatos, Rhoda, Sanz, Alberto
• Format: Journal Article
• Language: English
• Published: England 01.03.2018
• Subjects: Adenosine Triphosphate - genetics; Adenosine Triphosphate - metabolism; aging; Aging - genetics; Aging - metabolism; Aging - pathology; Animals; brain; Brain - metabolism; Brain - pathology; energy; Energy Metabolism; Humans; longevity; metabolism; mitochondria; Mitochondria - genetics; Mitochondria - metabolism; Mitochondria - pathology; mitosis; Neurodegenerative Diseases - genetics; Neurodegenerative Diseases - metabolism; Neurodegenerative Diseases - pathology; oxidative stress; reactive oxygen species; Reactive Oxygen Species - metabolism; Signal Transduction; signalling; aging; brain; mitochondria; signalling; reactive oxygen species

The brain is the most complex human organ, consuming more energy than any other tissue in proportion to its size. It relies heavily on mitochondria to produce energy and is made up of mitotic and postmitotic cells that need to closely coordinate their metabolism to maintain essential bodily function...