Architecture and function of NMDA receptors: an evolutionary perspective

• Published in: The Journal of physiology Vol. 599; no. 10; pp. 2615 - 2638
• Main Authors: Stroebel, David, Paoletti, Pierre
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.05.2021; Wiley
• Subjects: Allosteric properties; Biochemistry, Molecular Biology; Biodiversity; Central nervous system; Channel gating; evolution; Evolutionary genetics; glutamate receptors; Glutamic acid receptors; Glutamic acid receptors (ionotropic); Intracellular signalling; Ion channels; Life Sciences; Ligands; ligand‐gated ion channels; Molecular biology; N-Methyl-D-aspartic acid receptors; Nervous system; Neurobiology; Neurons and Cognition; Neurotransmission; NMDA; Phylogeny; Populations and Evolution; Receptor mechanisms; Structural Biology; synapse; Synaptic plasticity; NMDA; neurotransmission; evolution; synapse; ligand-gated ion channels; glutamate receptors; glutamate! receptors; phylogeny
• ISSN: 0022-3751; 1469-7793; 1469-7793
• DOI: 10.1113/JP279028

Ionotropic glutamate receptors (iGluRs) are a major class of ligand‐gated ion channels that are widespread in the living kingdom. Their critical role in excitatory neurotransmission and brain function of arthropods and vertebrates has made them a compelling subject of interest for neurophysiologists...