Immunomodulatory effects of low dose chemotherapy and perspectives of its combination with immunotherapy

• Published in: International journal of cancer Vol. 132; no. 11; pp. 2471 - 2478
• Main Authors: Nars, Mariana S., Kaneno, Ramon
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.06.2013; Wiley-Blackwell; Wiley Subscription Services, Inc
• Subjects: Animals; Antineoplastic Agents - administration & dosage; Biological and medical sciences; Cancer; Chemotherapy; Combined Modality Therapy; dendritic cells; Humans; Immunologic Factors - administration & dosage; Immunotherapy; Medical research; Medical sciences; metronomic; Neoplasms - immunology; Neoplasms - therapy; Treg; Tumors; vaccine; Dendritic cell; Immunomodulation; Low dose; Treg; Vaccine; Posology; Immunoprophylaxis; Chemotherapy; Perspective; metronomic; Treatment; Cancerology; dendritic cells; Antigen presenting cell; Immunotherapy

Given that cancer is one of the main causes of death worldwide, many efforts have been directed toward discovering new treatments and approaches to cure or control this group of diseases. Chemotherapy is the main treatment for cancer; however, a conventional schedule based on maximum tolerated dose...