Elevation of nitrotyrosine and nitrate concentrations in cystic fibrosis sputum

• Published in: Pediatric pulmonology Vol. 30; no. 2; pp. 79 - 85
• Main Authors: Jones, Kimberly L., Hegab, Alaa H., Hillman, Bettina C., Simpson, Keith L., Jinkins, Patricia A., Grisham, Matthew B., Owens, Michael W., Sato, Etsuro, Robbins, Richard A.
• Format: Journal Article Conference Proceeding
• Language: English
• Published: New York John Wiley & Sons, Inc 01.08.2000; Wiley-Liss
• Subjects: Adolescent; Adult; Biological and medical sciences; cystic fibrosis; Cystic Fibrosis - physiopathology; Female; Free Radicals - metabolism; Gastroenterology. Liver. Pancreas. Abdomen; Humans; Inflammation; Liver. Biliary tract. Portal circulation. Exocrine pancreas; lung disease; Male; Medical sciences; myeloperoxidase; nitrate; Nitrates - analysis; nitric oxide; Nitric Oxide - analysis; Nitric Oxide - metabolism; nitrotyrosine; Other diseases. Semiology; oxidants; oxygen radicals; peroxynitrite; Sputum - chemistry; superoxide; Superoxides - metabolism; Tyrosine - analogs & derivatives; Tyrosine - analysis; Human; Tyrosine; Nitration; Pathophysiology; Respiratory disease; Expiration; Metabolic diseases; Exploration; Cystic fibrosis; Biosynthesis; Inflammation; Nitrates; Genetic disease; Hyperoxides; Nitric oxide; Sputum; Digestive diseases; Pancreatic disease

Nitric oxide (NO) is increased in the exhaled air of some patients with inflammatory lung disorders, but not in others. NO may combine with superoxide to form peroxynitrite, which lowers NO gas concentrations, increases formation of nitrate, and increases nitration of tyrosine residues on proteins....