NetCoMi: network construction and comparison for microbiome data in R

• Published in: Briefings in bioinformatics Vol. 22; no. 4
• Main Authors: Peschel, Stefanie, Müller, Christian L, von Mutius, Erika, Boulesteix, Anne-Laure, Depner, Martin
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.07.2021; Oxford Publishing Limited (England)
• Subjects: Associations; Bioinformatics; Computer applications; Computer graphics; Data analysis; Estimation; Heterogeneity; Method Review; Microbial activity; Microbiomes; Microorganisms; Networks; Next-generation sequencing; Secondary analysis; Software; Statistical methods; Workflow; network analysis; compositional data; differential association; network comparison; sample similarity network; microbial association estimation

Abstract Motivation Estimating microbial association networks from high-throughput sequencing data is a common exploratory data analysis approach aiming at understanding the complex interplay of microbial communities in their natural habitat. Statistical network estimation workflows comprise several...