Cooperative effect of antisense-Rb and antisense-p53 oligomers on the extension of life span in human diploid fibroblasts, TIG-1
Normal human diploid fibroblasts, TIG-1, which have a replicative life span of about 62 population doublings (PD), tended to senesce after about 50 PD with a gradual decrease in sensitivity to serum. Treatment of TIG-1 cells with the antisense-Rb oligomer, which completely depleted the retinoblastom...
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Published in | Biochemical and biophysical research communications Vol. 179; no. 1; pp. 528 - 534 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
San Diego, CA
Elsevier Inc
30.08.1991
Elsevier |
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Abstract | Normal human diploid fibroblasts, TIG-1, which have a replicative life span of about 62 population doublings (PD), tended to senesce after about 50 PD with a gradual decrease in sensitivity to serum. Treatment of TIG-1 cells with the antisense-Rb oligomer, which completely depleted the retinoblastoma susceptibility gene product (RB), extended life span by about 10 PD. Treatment with the antisense-p53 oligomer alone had no effect; however, cotreatment with the antisense-Rb oligomer further potentiated the extension and the increased sensitivity to serum caused by the antisense-Rb oligomer alone, suggesting that p53 and RB function in separate, yet complementary pathways in signal transduction to senescence. The c-
fos expression, which is presumed to be regulated negatively by RB, was not stimulated in partially senescent TIG-1 cells by treatment with the antisense-Rb oligomer. |
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AbstractList | Normal human diploid fibroblasts, TIG-1, which have a replicative life span of about 62 population doublings (PD), tended to senesce after about 50 PD with a gradual decrease in sensitivity to serum. Treatment of TIG-1 cells with the antisense-Rb oligomer, which completely depleted the retinoblastoma susceptibility gene product (RB), extended life span by about 10 PD. Treatment with the antisense-p53 oligomer alone had no effect; however, cotreatment with the antisense-Rb oligomer further potentiated the extension and the increased sensitivity to serum caused by the antisense-Rb oligomer alone, suggesting that p53 and RB function in separate, yet complementary pathways in signal transduction to senescence. The c-fos expression, which is presumed to be regulated negatively by RB, was not stimulated in partially senescent TIG-1 cells by treatment with the antisense-Rb oligomer. Normal human diploid fibroblasts, TIG-1, which have a replicative life span of about 62 population doublings (PD), tended to senesce after about 50 PD with a gradual decrease in sensitivity to serum. Treatment of TIG-1 cells with the antisense-Rb oligomer, which completely depleted the retinoblastoma susceptibility gene product (RB), extended life span by about 10 PD. Treatment with the antisense-p53 oligomer alone had no effect; however, cotreatment with the antisense-Rb oligomer further potentiated the extension and the increased sensitivity to serum caused by the antisense-Rb oligomer alone, suggesting that p53 and RB function in separate, yet complementary pathways in signal transduction to senescence. The c- fos expression, which is presumed to be regulated negatively by RB, was not stimulated in partially senescent TIG-1 cells by treatment with the antisense-Rb oligomer. Normal human diploid fibroblasts, TIG-1, which have a replicative life span of about 62 population doublings (PD), tended to senesce after about 50 PD with a gradual decrease in sensitivity to serum. Treatment of TIG-1 cells with the antisense-RB oligomer, which completely depleted the retinoblastoma susceptibility gene product (RB), extended life span by about 10 PD. Treatment with the antisense-Rb oligomer further potentiated the extension and the increased sensitivity to serum caused by the antisense-Rb oligomer alone, suggesting that p53 and RB function in separate, yet complementary pathways in signal transduction to senescence. The c-fos expression, which is presumed to be regulated negatively by RB, was not stimulated in partially senescent TIG-1 cells by treatment with the antisense-Rb oligomer. (DBO) |
Author | Tsurui, Hiromichi Oda, Kinichiro Nakada, Susumu Shinozaki, Ayako Hara, Eiji |
Author_xml | – sequence: 1 givenname: Eiji surname: Hara fullname: Hara, Eiji organization: Department of Applied Biological Science, Science University of Tokyo, Chiba 278, Japan – sequence: 2 givenname: Hiromichi surname: Tsurui fullname: Tsurui, Hiromichi organization: Department of Pathology, Juntendo University School of Medicine, Tokyo 113, Japan – sequence: 3 givenname: Ayako surname: Shinozaki fullname: Shinozaki, Ayako organization: Department of Pathology, Juntendo University School of Medicine, Tokyo 113, Japan – sequence: 4 givenname: Susumu surname: Nakada fullname: Nakada, Susumu organization: Department of Biological Science and Technology, Science University of Tokyo, Chiba 278, Japan – sequence: 5 givenname: Kinichiro surname: Oda fullname: Oda, Kinichiro organization: Department of Biological Science and Technology, Science University of Tokyo, Chiba 278, Japan |
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Cites_doi | 10.1016/0092-8674(91)90641-B 10.1126/science.2237430 10.1126/science.2218499 10.1016/0531-5565(80)90083-2 10.1126/science.2204114 10.1038/346668a0 10.1016/0092-8674(90)90409-8 10.1128/jvi.65.1.505-510.1991 10.1016/0014-4827(65)90211-9 10.1126/science.2104680 10.1126/science.2421407 10.1126/science.2166342 10.1093/geronj/38.5.513 10.1016/0014-4827(84)90575-5 10.1128/jvi.65.1.473-478.1991 |
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Keywords | RB DMEM SDS PD FCS PDL HDF HPV Human Lifetime Senescence Antisense DNA Oligodeoxyribonucleotide Fibroblast Cooperative phenomenon Tumor suppressor gene |
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References | Hayflick (BIB1) 1965; 37 Lumpkin, McClung, Pereira-Smith, Smith (BIB4) 1986; 232 Crook, Fisher, Vousden (BIB17) 1991; 65 Maier, Voulalas, Roeder, Maclag (BIB21) 1990; 249 Seshadri, Capmisi (BIB15) 1990; 247 Ide, Tsuji, Nakashima, Ishibashi (BIB6) 1984; 150 Halbert, Demers, Galloway (BIB18) 1991; 65 Zamecnik, Goodchild, Taguchi, Sarin (BIB11) 1986; 83 Scheffner, Werness, Huibregtse, Levine, Howley (BIB19) 1990; 63 Pereira-Smith, Smith (BIB3) 1988; 85 Plisko, Gilchrest (BIB2) 1983; 38 Furukawa, Piwnica-Worms, Ernst, Kanakura, Griffin (BIB12) 1990; 250 Marshall (BIB5) 1991; 64 Matsukura, Shinozuka, Zon, Mitsuya, Reitz, Cohen, Broder (BIB10) 1987; 84 Reed, Stein, Subasinghe, Haldar, Croce, Yum, Cohen (BIB13) 1990; 50 Stein, Beeson, Gordon (BIB8) 1990; 249 Goldstein (BIB14) 1990; 249 Robbins, Horowitz, Mulligan (BIB16) 1990; 346 Bischoff, Friedman, Marshak, Prives, Beach (BIB20) 1990; 87 Wright, Pereira-Smith, Shay (BIB7) 1989; 9 Ohashi, Aizawa, Ooka, Ohsawa, Kaji, Kondo, Kobayashi, Nomura, Matsuo, Mitsui, Murota, Yamamoto, Ito, Shimada, Utakoji (BIB9) 1980; 15 Ide (10.1016/0006-291X(91)91403-Y_BIB6) 1984; 150 Ohashi (10.1016/0006-291X(91)91403-Y_BIB9) 1980; 15 Wright (10.1016/0006-291X(91)91403-Y_BIB7) 1989; 9 Matsukura (10.1016/0006-291X(91)91403-Y_BIB10) 1987; 84 Maier (10.1016/0006-291X(91)91403-Y_BIB21) 1990; 249 Goldstein (10.1016/0006-291X(91)91403-Y_BIB14) 1990; 249 Halbert (10.1016/0006-291X(91)91403-Y_BIB18) 1991; 65 Pereira-Smith (10.1016/0006-291X(91)91403-Y_BIB3) 1988; 85 Reed (10.1016/0006-291X(91)91403-Y_BIB13) 1990; 50 Stein (10.1016/0006-291X(91)91403-Y_BIB8) 1990; 249 Bischoff (10.1016/0006-291X(91)91403-Y_BIB20) 1990; 87 Crook (10.1016/0006-291X(91)91403-Y_BIB17) 1991; 65 Seshadri (10.1016/0006-291X(91)91403-Y_BIB15) 1990; 247 Scheffner (10.1016/0006-291X(91)91403-Y_BIB19) 1990; 63 Lumpkin (10.1016/0006-291X(91)91403-Y_BIB4) 1986; 232 Hayflick (10.1016/0006-291X(91)91403-Y_BIB1) 1965; 37 Plisko (10.1016/0006-291X(91)91403-Y_BIB2) 1983; 38 Zamecnik (10.1016/0006-291X(91)91403-Y_BIB11) 1986; 83 Furukawa (10.1016/0006-291X(91)91403-Y_BIB12) 1990; 250 Marshall (10.1016/0006-291X(91)91403-Y_BIB5) 1991; 64 Robbins (10.1016/0006-291X(91)91403-Y_BIB16) 1990; 346 |
References_xml | – volume: 232 start-page: 393 year: 1986 end-page: 395 ident: BIB4 publication-title: Science contributor: fullname: Smith – volume: 65 start-page: 505 year: 1991 end-page: 510 ident: BIB17 publication-title: J. Virol contributor: fullname: Vousden – volume: 249 start-page: 1570 year: 1990 end-page: 1574 ident: BIB21 publication-title: Science contributor: fullname: Maclag – volume: 65 start-page: 473 year: 1991 end-page: 478 ident: BIB18 publication-title: J. Virol contributor: fullname: Galloway – volume: 84 start-page: 7706 year: 1987 end-page: 7710 ident: BIB10 publication-title: Proc. Natl. Acad. Sci. USA contributor: fullname: Broder – volume: 250 start-page: 805 year: 1990 end-page: 808 ident: BIB12 publication-title: Science contributor: fullname: Griffin – volume: 63 start-page: 1129 year: 1990 end-page: 1136 ident: BIB19 publication-title: Cell contributor: fullname: Howley – volume: 64 start-page: 313 year: 1991 end-page: 395 ident: BIB5 publication-title: Cell contributor: fullname: Marshall – volume: 150 start-page: 321 year: 1984 end-page: 328 ident: BIB6 publication-title: Exp. Cell. Res contributor: fullname: Ishibashi – volume: 15 start-page: 121 year: 1980 end-page: 133 ident: BIB9 publication-title: Exp. Gerontol contributor: fullname: Utakoji – volume: 249 start-page: 1129 year: 1990 end-page: 1133 ident: BIB14 publication-title: Science contributor: fullname: Goldstein – volume: 346 start-page: 668 year: 1990 end-page: 671 ident: BIB16 publication-title: Nature contributor: fullname: Mulligan – volume: 249 start-page: 666 year: 1990 end-page: 669 ident: BIB8 publication-title: Science contributor: fullname: Gordon – volume: 38 start-page: 513 year: 1983 end-page: 518 ident: BIB2 publication-title: J. Gerontol contributor: fullname: Gilchrest – volume: 37 start-page: 614 year: 1965 end-page: 636 ident: BIB1 publication-title: Exp. Cell Res contributor: fullname: Hayflick – volume: 85 start-page: 6042 year: 1988 end-page: 6046 ident: BIB3 publication-title: Proc. Natl. Acad. Sci. USA contributor: fullname: Smith – volume: 87 start-page: 4766 year: 1990 end-page: 4770 ident: BIB20 publication-title: Proc. Natl. Acad. Sci. USA contributor: fullname: Beach – volume: 247 start-page: 205 year: 1990 end-page: 209 ident: BIB15 publication-title: Science contributor: fullname: Capmisi – volume: 9 start-page: 3088 year: 1989 end-page: 3092 ident: BIB7 publication-title: Mol. Cell Biol contributor: fullname: Shay – volume: 83 start-page: 4143 year: 1986 end-page: 4146 ident: BIB11 publication-title: Proc. Natl. Acad. Sci. USA contributor: fullname: Sarin – volume: 50 start-page: 6565 year: 1990 end-page: 6570 ident: BIB13 publication-title: Cancer Res contributor: fullname: Cohen – volume: 84 start-page: 7706 year: 1987 ident: 10.1016/0006-291X(91)91403-Y_BIB10 contributor: fullname: Matsukura – volume: 64 start-page: 313 year: 1991 ident: 10.1016/0006-291X(91)91403-Y_BIB5 publication-title: Cell doi: 10.1016/0092-8674(91)90641-B contributor: fullname: Marshall – volume: 250 start-page: 805 year: 1990 ident: 10.1016/0006-291X(91)91403-Y_BIB12 publication-title: Science doi: 10.1126/science.2237430 contributor: fullname: Furukawa – volume: 249 start-page: 1570 year: 1990 ident: 10.1016/0006-291X(91)91403-Y_BIB21 publication-title: Science doi: 10.1126/science.2218499 contributor: fullname: Maier – volume: 15 start-page: 121 year: 1980 ident: 10.1016/0006-291X(91)91403-Y_BIB9 publication-title: Exp. Gerontol doi: 10.1016/0531-5565(80)90083-2 contributor: fullname: Ohashi – volume: 85 start-page: 6042 year: 1988 ident: 10.1016/0006-291X(91)91403-Y_BIB3 contributor: fullname: Pereira-Smith – volume: 249 start-page: 1129 year: 1990 ident: 10.1016/0006-291X(91)91403-Y_BIB14 publication-title: Science doi: 10.1126/science.2204114 contributor: fullname: Goldstein – volume: 83 start-page: 4143 year: 1986 ident: 10.1016/0006-291X(91)91403-Y_BIB11 contributor: fullname: Zamecnik – volume: 346 start-page: 668 year: 1990 ident: 10.1016/0006-291X(91)91403-Y_BIB16 publication-title: Nature doi: 10.1038/346668a0 contributor: fullname: Robbins – volume: 63 start-page: 1129 year: 1990 ident: 10.1016/0006-291X(91)91403-Y_BIB19 publication-title: Cell doi: 10.1016/0092-8674(90)90409-8 contributor: fullname: Scheffner – volume: 65 start-page: 505 year: 1991 ident: 10.1016/0006-291X(91)91403-Y_BIB17 publication-title: J. Virol doi: 10.1128/jvi.65.1.505-510.1991 contributor: fullname: Crook – volume: 87 start-page: 4766 year: 1990 ident: 10.1016/0006-291X(91)91403-Y_BIB20 contributor: fullname: Bischoff – volume: 37 start-page: 614 year: 1965 ident: 10.1016/0006-291X(91)91403-Y_BIB1 publication-title: Exp. Cell Res doi: 10.1016/0014-4827(65)90211-9 contributor: fullname: Hayflick – volume: 50 start-page: 6565 year: 1990 ident: 10.1016/0006-291X(91)91403-Y_BIB13 publication-title: Cancer Res contributor: fullname: Reed – volume: 247 start-page: 205 year: 1990 ident: 10.1016/0006-291X(91)91403-Y_BIB15 publication-title: Science doi: 10.1126/science.2104680 contributor: fullname: Seshadri – volume: 232 start-page: 393 year: 1986 ident: 10.1016/0006-291X(91)91403-Y_BIB4 publication-title: Science doi: 10.1126/science.2421407 contributor: fullname: Lumpkin – volume: 249 start-page: 666 year: 1990 ident: 10.1016/0006-291X(91)91403-Y_BIB8 publication-title: Science doi: 10.1126/science.2166342 contributor: fullname: Stein – volume: 38 start-page: 513 year: 1983 ident: 10.1016/0006-291X(91)91403-Y_BIB2 publication-title: J. Gerontol doi: 10.1093/geronj/38.5.513 contributor: fullname: Plisko – volume: 150 start-page: 321 year: 1984 ident: 10.1016/0006-291X(91)91403-Y_BIB6 publication-title: Exp. Cell. Res doi: 10.1016/0014-4827(84)90575-5 contributor: fullname: Ide – volume: 65 start-page: 473 year: 1991 ident: 10.1016/0006-291X(91)91403-Y_BIB18 publication-title: J. Virol doi: 10.1128/jvi.65.1.473-478.1991 contributor: fullname: Halbert – volume: 9 start-page: 3088 year: 1989 ident: 10.1016/0006-291X(91)91403-Y_BIB7 publication-title: Mol. Cell Biol contributor: fullname: Wright |
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Snippet | Normal human diploid fibroblasts, TIG-1, which have a replicative life span of about 62 population doublings (PD), tended to senesce after about 50 PD with a... |
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SubjectTerms | Ageing, cell death Base Sequence Biological and medical sciences Cell Division - drug effects Cell Line Cell physiology Cell Survival - drug effects Codon - genetics Fibroblasts - cytology Fibroblasts - drug effects Fundamental and applied biological sciences. Psychology Genes, Retinoblastoma Humans Kinetics Molecular and cellular biology Molecular Sequence Data Oligonucleotides, Antisense - pharmacology Protein-Tyrosine Kinases - genetics Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins c-fos Proto-Oncogenes - drug effects Retinoblastoma Protein - genetics Time Factors Tumor Suppressor Protein p53 - genetics |
Title | Cooperative effect of antisense-Rb and antisense-p53 oligomers on the extension of life span in human diploid fibroblasts, TIG-1 |
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