Synthesis of Prostate-Specific Membrane Antigen-Targeted Bimodal Conjugates of Cytotoxic Agents and Antiandrogens and Their Comparative Assessment with Monoconjugates

• Published in: International journal of molecular sciences Vol. 24; no. 14; p. 11327
• Main Authors: Zyk, Nikolai Y., Garanina, Anastasiia S., Plotnikova, Ekaterina A., Ber, Anton P., Nimenko, Ekaterina A., Dashkova, Natalia S., Uspenskaia, Anastasiia A., Shafikov, Radik R., Skvortsov, Dmitry A., Petrov, Stanislav A., Pankratov, Andrey A., Zyk, Nikolai V., Majouga, Alexander G., Beloglazkina, Elena K., Machulkin, Aleksei E.
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 11.07.2023; MDPI
• Subjects: Amino acids; Antiandrogens; Antigens; Cancer therapies; Comparative analysis; Drugs; Health aspects; Ligands; Peptides; Prostate; Prostate cancer; Proteins; Russia; bimodal conjugates; targeted drug delivery; prostate cancer; monomethyl auristatin E; prostate-specific membrane antigen

Prostate cancer is the second most common cancer among men. We designed and synthesized new ligands targeting prostate-specific membrane antigen and suitable for bimodal conjugates with diagnostic and therapeutic agents. In vitro studies of the affinity of the synthesized compounds to the protein ta...