Synthesis of Prostate-Specific Membrane Antigen-Targeted Bimodal Conjugates of Cytotoxic Agents and Antiandrogens and Their Comparative Assessment with Monoconjugates

Prostate cancer is the second most common cancer among men. We designed and synthesized new ligands targeting prostate-specific membrane antigen and suitable for bimodal conjugates with diagnostic and therapeutic agents. In vitro studies of the affinity of the synthesized compounds to the protein ta...

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Published inInternational journal of molecular sciences Vol. 24; no. 14; p. 11327
Main Authors Zyk, Nikolai Y., Garanina, Anastasiia S., Plotnikova, Ekaterina A., Ber, Anton P., Nimenko, Ekaterina A., Dashkova, Natalia S., Uspenskaia, Anastasiia A., Shafikov, Radik R., Skvortsov, Dmitry A., Petrov, Stanislav A., Pankratov, Andrey A., Zyk, Nikolai V., Majouga, Alexander G., Beloglazkina, Elena K., Machulkin, Aleksei E.
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 11.07.2023
MDPI
Subjects
Amino acids
Antiandrogens
Antigens
Cancer therapies
Comparative analysis
Drugs
Health aspects
Ligands
Peptides
Prostate
Prostate cancer
Proteins
Russia
bimodal conjugates
targeted drug delivery
prostate cancer
monomethyl auristatin E
prostate-specific membrane antigen
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Abstract Prostate cancer is the second most common cancer among men. We designed and synthesized new ligands targeting prostate-specific membrane antigen and suitable for bimodal conjugates with diagnostic and therapeutic agents. In vitro studies of the affinity of the synthesized compounds to the protein target have been carried out. Based on these ligands, a series of bimodal conjugates with a combination of different mitosis inhibitors and antiandrogenic drugs were synthesized. The cytotoxicity of the compounds obtained in vitro was investigated on three different cell lines. The efficacy of the two obtained conjugates was evaluated in vivo in xenograft models of prostate cancer. These compounds have been shown to be highly effective in inhibiting the growth of PSMA-expressing tumors.
AbstractList Prostate cancer is the second most common cancer among men. We designed and synthesized new ligands targeting prostate-specific membrane antigen and suitable for bimodal conjugates with diagnostic and therapeutic agents. In vitro studies of the affinity of the synthesized compounds to the protein target have been carried out. Based on these ligands, a series of bimodal conjugates with a combination of different mitosis inhibitors and antiandrogenic drugs were synthesized. The cytotoxicity of the compounds obtained in vitro was investigated on three different cell lines. The efficacy of the two obtained conjugates was evaluated in vivo in xenograft models of prostate cancer. These compounds have been shown to be highly effective in inhibiting the growth of PSMA-expressing tumors.
Prostate cancer is the second most common cancer among men. We designed and synthesized new ligands targeting prostate-specific membrane antigen and suitable for bimodal conjugates with diagnostic and therapeutic agents. studies of the affinity of the synthesized compounds to the protein target have been carried out. Based on these ligands, a series of bimodal conjugates with a combination of different mitosis inhibitors and antiandrogenic drugs were synthesized. The cytotoxicity of the compounds obtained was investigated on three different cell lines. The efficacy of the two obtained conjugates was evaluated in xenograft models of prostate cancer. These compounds have been shown to be highly effective in inhibiting the growth of PSMA-expressing tumors.
Prostate cancer is the second most common cancer among men. We designed and synthesized new ligands targeting prostate-specific membrane antigen and suitable for bimodal conjugates with diagnostic and therapeutic agents. In vitro studies of the affinity of the synthesized compounds to the protein target have been carried out. Based on these ligands, a series of bimodal conjugates with a combination of different mitosis inhibitors and antiandrogenic drugs were synthesized. The cytotoxicity of the compounds obtained in vitro was investigated on three different cell lines. The efficacy of the two obtained conjugates was evaluated in vivo in xenograft models of prostate cancer. These compounds have been shown to be highly effective in inhibiting the growth of PSMA-expressing tumors.Prostate cancer is the second most common cancer among men. We designed and synthesized new ligands targeting prostate-specific membrane antigen and suitable for bimodal conjugates with diagnostic and therapeutic agents. In vitro studies of the affinity of the synthesized compounds to the protein target have been carried out. Based on these ligands, a series of bimodal conjugates with a combination of different mitosis inhibitors and antiandrogenic drugs were synthesized. The cytotoxicity of the compounds obtained in vitro was investigated on three different cell lines. The efficacy of the two obtained conjugates was evaluated in vivo in xenograft models of prostate cancer. These compounds have been shown to be highly effective in inhibiting the growth of PSMA-expressing tumors.
Prostate cancer is the second most common cancer among men. We designed and synthesized new ligands targeting prostate-specific membrane antigen and suitable for bimodal conjugates with diagnostic and therapeutic agents. In vitro studies of the affinity of the synthesized compounds to the protein target have been carried out. Based on these ligands, a series of bimodal conjugates with a combination of different mitosis inhibitors and antiandrogenic drugs were synthesized. The cytotoxicity of the compounds obtained in vitro was investigated on three different cell lines. The efficacy of the two obtained conjugates was evaluated in vivo in xenograft models of prostate cancer. These compounds have been shown to be highly effective in inhibiting the growth of PSMA-expressing tumors.
Audience Academic
Author Machulkin, Aleksei E.
Plotnikova, Ekaterina A.
Skvortsov, Dmitry A.
Ber, Anton P.
Uspenskaia, Anastasiia A.
Majouga, Alexander G.
Nimenko, Ekaterina A.
Garanina, Anastasiia S.
Dashkova, Natalia S.
Shafikov, Radik R.
Zyk, Nikolai Y.
Petrov, Stanislav A.
Zyk, Nikolai V.
Beloglazkina, Elena K.
Pankratov, Andrey A.
AuthorAffiliation 4 Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry Russian Academy of Sciences, GSP-7, Ulitsa Miklukho-Maklaya, 16/10, Moscow 117997, Russia
1 Chemistry Department, Lomonosov Moscow State University, Leninskie Gory, Building 1/3, GSP-1, Moscow 119991, Russia berantonmsu@gmail.com (A.P.B.); nata.dashkova1996@mail.ru (N.S.D.); uspenskaya.n@gmail.com (A.A.U.); iltarn@mail.ru (R.R.S.); skvorratd@mail.ru (D.A.S.); zyknikola@gmail.com (N.Y.Z.)
2 Laboratory of Biomedical Nanomaterials, National University of Science and Technology MISIS, 4 Leninskiy pr, Moscow 119049, Russia; anastasiacit@gmail.com
5 Dmitry Mendeleev University of Chemical Technology of Russia, Miusskaya sq. 9, Moscow 125047, Russia
3 National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation, 2 Botkinskiy proezd, 3, Moscow 125284, Russia; plotnikovaekaterina62@gmail.com (E.A.P.)
AuthorAffiliation_xml – name: 4 Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry Russian Academy of Sciences, GSP-7, Ulitsa Miklukho-Maklaya, 16/10, Moscow 117997, Russia
– name: 2 Laboratory of Biomedical Nanomaterials, National University of Science and Technology MISIS, 4 Leninskiy pr, Moscow 119049, Russia; anastasiacit@gmail.com
– name: 1 Chemistry Department, Lomonosov Moscow State University, Leninskie Gory, Building 1/3, GSP-1, Moscow 119991, Russia berantonmsu@gmail.com (A.P.B.); nata.dashkova1996@mail.ru (N.S.D.); uspenskaya.n@gmail.com (A.A.U.); iltarn@mail.ru (R.R.S.); skvorratd@mail.ru (D.A.S.); zyknikola@gmail.com (N.Y.Z.)
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/37511087$$D View this record in MEDLINE/PubMed
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CitedBy_id crossref_primary_10_1002_cmdc_202300720
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crossref_primary_10_31857_S0514749224020058
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Keywords bimodal conjugates
targeted drug delivery
prostate cancer
monomethyl auristatin E
prostate-specific membrane antigen
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Snippet Prostate cancer is the second most common cancer among men. We designed and synthesized new ligands targeting prostate-specific membrane antigen and suitable...
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StartPage 11327
SubjectTerms Amino acids
Antiandrogens
Antigens
Cancer therapies
Comparative analysis
Drugs
Health aspects
Ligands
Peptides
Prostate
Prostate cancer
Proteins
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Title Synthesis of Prostate-Specific Membrane Antigen-Targeted Bimodal Conjugates of Cytotoxic Agents and Antiandrogens and Their Comparative Assessment with Monoconjugates
URI https://www.ncbi.nlm.nih.gov/pubmed/37511087
https://www.proquest.com/docview/2843070629
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https://pubmed.ncbi.nlm.nih.gov/PMC10380083
Volume 24
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