The eyes absent gene: Genetic control of cell survival and differentiation in the developing Drosophila eye

• Published in: Cell Vol. 72; no. 3; pp. 379 - 395
• Main Authors: Bonini, Nancy M., Leiserson, William M., Benzer, Seymour
• Format: Journal Article
• Language: English
• Published: Cambridge, MA Elsevier Inc 12.02.1993; Cell Press
• Subjects: Alleles; Amino Acid Sequence; Animals; Base Sequence; Biological and medical sciences; Cell Differentiation; Cell Division; Cell Survival; Cloning, Molecular; DNA - genetics; Drosophila; Drosophila melanogaster - embryology; Drosophila melanogaster - genetics; Eye - cytology; Eye - embryology; Fundamental and applied biological sciences. Psychology; Gene Expression; Genes, Insect; Genes. Genome; Molecular and cellular biology; Molecular genetics; Molecular Sequence Data; Morphogenesis; Oligonucleotides - chemistry; Restriction Mapping; RNA, Messenger - genetics; Immunocytochemistry; Insecta; Inheritance; Histology; Cell differentiation; Drosophilidae; Morphogenesis; Eye; Cell death; Arthropoda; Mutation; Invertebrata; Drosophila melanogaster; Diptera

The eyes absent (eya) gene is required at an early stage in development of the D. melanogaster compound eye. In eya mutants, progenitor cells in the eye disc undergo programmed cell death anterior to the morphogenetic furrow, rather than proceeding into the pathway of retinal differentiation. A low...