Prevalence and Prognostic Implications of Discordant Grading and Flow-Gradient Patterns in Moderate Aortic Stenosis

• Published in: Journal of the American College of Cardiology Vol. 80; no. 7; pp. 666 - 676
• Main Authors: Stassen, Jan, Ewe, See Hooi, Singh, Gurpreet K., Butcher, Steele C., Hirasawa, Kensuke, Amanullah, Mohammed R., Pio, Stephan M., Sin, Kenny Y.K., Ding, Zee P., Sia, Ching-Hui, Chew, Nicholas W.S., Kong, William K.F., Poh, Kian Keong, Leon, Martin B., Pibarot, Philippe, Delgado, Victoria, Marsan, Nina Ajmone, Bax, Jeroen J.
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 16.08.2022
• Subjects: Cardiovascular; discordant grading; low-flow; low-gradient aortic stenosis; moderate aortic stenosis; mortality; discordant grading; low-gradient aortic stenosis; AS; SVi; moderate aortic stenosis; mortality; LVEF; low-flow; LV; MG; AVA; AVR; aortic valve replacement; left ventricular/ventricle; stroke volume index; left ventricular ejection fraction; aortic stenosis; mean gradient; aortic valve area
• ISSN: 0735-1097; 1558-3597; 1558-3597
• DOI: 10.1016/j.jacc.2022.05.036

The prognostic implications of discordant grading in severe aortic stenosis (AS) are well known. However, the prevalence of different flow-gradient patterns and their prognostic implications in moderate AS are unknown. The purpose of this study was to investigate the occurrence and prognostic implications of different flow-gradient patterns in patients with moderate AS. Patients with moderate AS (aortic valve area >1.0 and ≤1.5 cm2) were identified and divided in 4 groups based on transvalvular mean gradient (MG), stroke volume index (SVi), and left ventricular ejection fraction (LVEF): concordant moderate AS (MG ≥20 mm Hg) and discordant moderate AS including 3 subgroups: normal-flow, low-gradient moderate AS (MG <20 mm Hg, SVi ≥35 mL/m2, and LVEF ≥50%); “paradoxical” low-flow, low-gradient moderate AS (MG <20 mm Hg, SVi <35 mL/m2, and LVEF ≥50%) and “classical” low-flow, low-gradient moderate AS (MG <20 mm Hg and LVEF <50%). The primary endpoint was all-cause mortality. Of 1,974 patients (age 73 ± 10 years, 51% men) with moderate AS, 788 (40%) had discordant grading, and these patients showed significantly higher mortality rates than patients with concordant moderate AS (P < 0.001). On multivariable analysis, “paradoxical” low-flow, low-gradient (HR: 1.458; 95% CI: 1.072-1.983; P = 0.014) and “classical” low-flow, low-gradient (HR: 1.710; 95% CI: 1.270-2.303; P < 0.001) patterns but not the normal-flow, low-gradient moderate AS pattern were independently associated with all-cause mortality. Discordant grading is frequently (40%) observed in patients with moderate AS. Low-flow, low-gradient patterns account for an important proportion of the discordant cases and are associated with increased mortality. These findings underline the need for better phenotyping patients with discordant moderate AS. [Display omitted]