MicroRNA-146b: A Novel Biomarker and Therapeutic Target for Human Papillary Thyroid Cancer

• Published in: International journal of molecular sciences Vol. 18; no. 3; p. 636
• Main Authors: Chou, Chen-Kai, Liu, Rue-Tusan, Kang, Hong-Yo
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI 15.03.2017; MDPI AG
• Subjects: Animals; Biomarkers, Tumor; Carcinoma - diagnosis; Carcinoma - genetics; Carcinoma - metabolism; Carcinoma - therapy; Carcinoma, Papillary; Cell Transformation, Neoplastic - genetics; Disease Progression; Gene Expression Regulation, Neoplastic; Humans; Lymphatic Metastasis; microRNA-146b; MicroRNAs - chemistry; MicroRNAs - genetics; Molecular Targeted Therapy; Mutation; papillary thyroid carcinoma; Prognosis; Recurrence; Review; RNA Interference; Signal Transduction; target gene; Thyroid Cancer, Papillary; Thyroid Neoplasms - diagnosis; Thyroid Neoplasms - genetics; Thyroid Neoplasms - metabolism; Thyroid Neoplasms - therapy; tumorigenesis; microRNA-146b; tumorigenesis; papillary thyroid carcinoma; target gene

Papillary thyroid cancer (PTC) is the most common tumor subtype of thyroid cancer. However, not all PTCs are responsive to current surgical and radioiodine treatment. The well-established clinical prognostic factors include tumor size, lymph node/distal metastasis, and extrathyroidal invasion. The /...