Human Leukocyte Antigen Haplotypes in the Genetic Control of Immune Response to Measles-Mumps-Rubella Vaccine

• Published in: The Journal of infectious diseases Vol. 193; no. 5; pp. 655 - 663
• Main Authors: Ovsyannikova, Inna G., Pankratz, V. Shane, Vierkant, Robert A., Jacobson, Robert M., Poland, Gregory A.
• Format: Journal Article
• Language: English
• Published: Chicago, IL The University of Chicago Press 01.03.2006; University of Chicago Press; Oxford University Press
• Subjects: Adolescent; Antibodies; Antibodies, Viral - blood; Applied microbiology; Biological and medical sciences; Child; Fundamental and applied biological sciences. Psychology; Haplotypes; HLA antigens; HLA Antigens - genetics; HLA Antigens - immunology; Human viral diseases; Humans; Immune response; Immunity, Cellular; Immunoglobulin G - blood; Infectious diseases; Lymphocyte Activation; Lymphocytes - immunology; Measels mumps rubella vaccine; Measles; Measles virus; Measles virus - immunology; Measles-Mumps-Rubella Vaccine - immunology; Medical sciences; Microbiology; Mumps; Mumps virus; Mumps virus - immunology; Rubella; Rubella virus; Statistics as Topic; Vaccination; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects); Viral diseases; Viral diseases with cutaneous or mucosal lesions and viral diseases of the eye; Viruses; Infection; Rubella; HLA-System; Immune response; Microbiology; Viral disease; Measles; Vaccine; Mumps; Genetic determinism; Haplotype
• ISSN: 0022-1899; 1537-6613
• DOI: 10.1086/500144

To elucidate the contribution of human leukocyte antigen (HLA) haplotypes and their genotypic combinations to immune status after measles-mumps-rubella (MMR) vaccination, 346 children 12–18 years of age were studied. The class I A*29-Cw*16-B*44 haplotype was associated with lower levels of immunoglobulin G (IgG) antibody to both measles (P=.08) and mumps (P=.03) viral antigens. The A*26-Cw*12-B*38 haplotype was associated with higher cellular immune responses to measles (P=.02) and mumps (P=.01) vaccine viruses. Subjects with the class II DRB1*03-DQB1*02-DPB1*04 haplotype had higher lymphoproliferative responses to measles virus (P=.01) and mumps virus (P=.006). The DRB1*15/16-DQB1*06-DPB1*03 haplotype was associated with high levels of IgG antibody to measles virus (P=.09) but low levels of IgG antibody to rubella virus (P=.02), whereas DRB1*04-DQB1*03-DPB1*03 was associated with high lymphoproliferative responses to both measles (P=.01) and rubella (P=.002) vaccine viruses. A*26-Cw*12-B*38 was associated with both mumps virus–specific humoral (P=.007) and cell-mediated (P=.01) immune responses after 2 doses of MMR vaccine. Haplotype DRB1*04-DQB1*03-DPB1*03 was associated with both lower rubella virus IgG antibody levels (P=.02) and higher rubella virus–specific lymphoproliferation (P=.002). Better characterization of such HLA profiles could inform and improve the design of novel epitope-rich vaccines and help to predict protective immune responses at the individual and population level