Therapeutic Efficiency of Proteins Secreted by Glial Progenitor Cells in a Rat Model of Traumatic Brain Injury

• Published in: International journal of molecular sciences Vol. 24; no. 15; p. 12341
• Main Authors: Salikhova, Diana I., Golovicheva, Victoria V., Fatkhudinov, Timur Kh, Shevtsova, Yulia A., Soboleva, Anna G., Goryunov, Kirill V., Dyakonov, Alexander S., Mokroysova, Victoria O., Mingaleva, Natalia S., Shedenkova, Margarita O., Makhnach, Oleg V., Kutsev, Sergey I., Chekhonin, Vladimir P., Silachev, Denis N., Goldshtein, Dmitry V.
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.08.2023; MDPI
• Subjects: Animals; Apolipoproteins; Apoptosis; Asymmetry; Brain; Brain damage; Brain Injuries, Traumatic - metabolism; Cell cycle; Endothelial Cells - metabolism; Enzymes; Inflammation; Injuries; Metabolism; Molecular weight; Neuroglia - metabolism; Neurons; Oxidative stress; Proteins; Proteomics; Rats; Rats, Sprague-Dawley; Scientific equipment and supplies industry; Stem Cells - metabolism; Traumatic brain injury; United States; Germany; Russia; traumatic brain injury; glial cells; iPSCs; secretome; proteomic analysis

Traumatic brain injuries account for 30–50% of all physical traumas and are the most common pathological diseases of the brain. Mechanical damage of brain tissue leads to the disruption of the blood–brain barrier and the massive death of neuronal, glial, and endothelial cells. These events trigger a...