The evolution of the glandular kallikrein locus: identification of orthologs and pseudogenes in the cotton-top tamarin

• Published in: Gene Vol. 343; no. 2; pp. 347 - 355
• Main Authors: Olsson, A. Yvonne, Valtonen-André, Camilla, Lilja, Hans, Lundwall, Åke
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 22.12.2004
• Subjects: 5' Untranslated Regions - genetics; Amino Acid Sequence; Animals; ARE; Base Sequence; Basic Medicine; Conserved Sequence; Enhancer; Evolution; Evolution, Molecular; Humans; Kallikreins - genetics; Luciferases - metabolism; Läkemedelskemi; Medical and Health Sciences; Medicin och hälsovetenskap; Medicinal Chemistry; Medicinska och farmaceutiska grundvetenskaper; Mice; Molecular Sequence Data; Phylogeny; Prostate-specific antigen; Pseudogenes; Rats; Saguinus - genetics; Saguinus oedipus; Tissue Kallikreins - genetics; Transcription, Genetic; AR; KLK1; KLK2A2; ARE; Enhancer; KLK2A1; Prostate-specific antigen; Evolution; hK2; hK1; PSA

Comparisons of the glandular kallikreins loci in human, mouse and rat revealed remarkable differences. For example, the mouse and the rat lack the genes encoding prostate-specific antigen (PSA) and human glandular kallikrein 2 (hK2). In contrast, the intergenic region between KLK1 and KLK15 is devoi...