Identification of PB2 Mutations Responsible for the Efficient Replication of H5N1 Influenza Viruses in Human Lung Epithelial Cells

• Published in: Journal of virology Vol. 89; no. 7; pp. 3947 - 3956
• Main Authors: Yamaji, Reina, Yamada, Shinya, Le, Mai Q., Li, Chengjun, Chen, Hualan, Qurnianingsih, Ema, Nidom, Chairul A., Ito, Mutsumi, Sakai-Tagawa, Yuko, Kawaoka, Yoshihiro
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 01.04.2015
• Subjects: Adaptation, Biological; Cell Line; Epithelial Cells - virology; Genetic Diversity and Evolution; Humans; Influenza A Virus, H5N1 Subtype - genetics; Influenza A Virus, H5N1 Subtype - physiology; Influenza virus; Mutant Proteins - genetics; Mutant Proteins - metabolism; Mutation, Missense; Recombination, Genetic; Reverse Genetics; Viral Proteins - genetics; Viral Proteins - metabolism; Virus Replication; ISEW, Vietnam

Highly pathogenic H5N1 avian influenza viruses have caused outbreaks among poultry worldwide, resulting in sporadic infections in humans with approximately 60% mortality. However, efficient transmission of H5N1 viruses among humans has yet to occur, suggesting that further adaptation of H5N1 viruses...