Roles of the immune system in cancer: from tumor initiation to metastatic progression

• Published in: Genes & development Vol. 32; no. 19-20; pp. 1267 - 1284
• Main Authors: Gonzalez, Hugo, Hagerling, Catharina, Werb, Zena
• Format: Journal Article
• Language: English
• Published: United States Cold Springs Harbor Laboratory Press 01.10.2018; Cold Spring Harbor Laboratory Press
• Subjects: B-Lymphocytes - immunology; BASIC BIOLOGICAL SCIENCES; cancer heterogeneity; Carcinoma - immunology; Carcinoma - secondary; Dendritic Cells - immunology; Disease Progression; disseminated tumor cells; Humans; immune cross-talk; Immunologic Surveillance; Inflammation - immunology; Killer Cells, Natural - immunology; Macrophages - immunology; metastasis-associated immune cells; Neoplasm Metastasis - immunology; Neoplasms - immunology; Neutrophils - immunology; patient-derived xenograft; Review; T-Lymphocytes - immunology; tumor-associated macrophages; disseminated tumor cells; immune cross-talk; patient-derived xenograft; cancer heterogeneity; metastasis-associated immune cells; tumor-associated macrophages

The presence of inflammatory immune cells in human tumors raises a fundamental question in oncology: How do cancer cells avoid the destruction by immune attack? In principle, tumor development can be controlled by cytotoxic innate and adaptive immune cells; however, as the tumor develops from neopla...