Roles of the immune system in cancer: from tumor initiation to metastatic progression
The presence of inflammatory immune cells in human tumors raises a fundamental question in oncology: How do cancer cells avoid the destruction by immune attack? In principle, tumor development can be controlled by cytotoxic innate and adaptive immune cells; however, as the tumor develops from neopla...
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| Published in | Genes & development Vol. 32; no. 19-20; pp. 1267 - 1284 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Cold Springs Harbor Laboratory Press
01.10.2018
Cold Spring Harbor Laboratory Press |
| Subjects | |
| Online Access | Get full text |
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| Abstract | The presence of inflammatory immune cells in human tumors raises a fundamental question in oncology: How do cancer cells avoid the destruction by immune attack? In principle, tumor development can be controlled by cytotoxic innate and adaptive immune cells; however, as the tumor develops from neoplastic tissue to clinically detectable tumors, cancer cells evolve different mechanisms that mimic peripheral immune tolerance in order to avoid tumoricidal attack. Here, we provide an update of recent accomplishments, unifying concepts, and future challenges to study tumor-associated immune cells, with an emphasis on metastatic carcinomas. |
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| AbstractList | The presence of inflammatory immune cells in human tumors raises a fundamental question in oncology: How do cancer cells avoid the destruction by immune attack? In principle, tumor development can be controlled by cytotoxic innate and adaptive immune cells; however, as the tumor develops from neoplastic tissue to clinically detectable tumors, cancer cells evolve different mechanisms that mimic peripheral immune tolerance in order to avoid tumoricidal attack. Here in this paper, we provide an update of recent accomplishments, unifying concepts, and future challenges to study tumor-associated immune cells, with an emphasis on metastatic carcinomas. The presence of inflammatory immune cells in human tumors raises a fundamental question in oncology: How do cancer cells avoid the destruction by immune attack? In principle, tumor development can be controlled by cytotoxic innate and adaptive immune cells; however, as the tumor develops from neoplastic tissue to clinically detectable tumors, cancer cells evolve different mechanisms that mimic peripheral immune tolerance in order to avoid tumoricidal attack. Here, we provide an update of recent accomplishments, unifying concepts, and future challenges to study tumor-associated immune cells, with an emphasis on metastatic carcinomas. In this review, Gonzelez et al. provide an update of recent accomplishments, unifying concepts, and futures challenges to study tumor-associated immune cells, with an emphasis on metastatic carcinomas. The presence of inflammatory immune cells in human tumors raises a fundamental question in oncology: How do cancer cells avoid the destruction by immune attack? In principle, tumor development can be controlled by cytotoxic innate and adaptive immune cells; however, as the tumor develops from neoplastic tissue to clinically detectable tumors, cancer cells evolve different mechanisms that mimic peripheral immune tolerance in order to avoid tumoricidal attack. Here, we provide an update of recent accomplishments, unifying concepts, and future challenges to study tumor-associated immune cells, with an emphasis on metastatic carcinomas. The presence of inflammatory immune cells in human tumors raises a fundamental question in oncology: How do cancer cells avoid the destruction by immune attack? In principle, tumor development can be controlled by cytotoxic innate and adaptive immune cells; however, as the tumor develops from neoplastic tissue to clinically detectable tumors, cancer cells evolve different mechanisms that mimic peripheral immune tolerance in order to avoid tumoricidal attack. Here, we provide an update of recent accomplishments, unifying concepts, and future challenges to study tumor-associated immune cells, with an emphasis on metastatic carcinomas.The presence of inflammatory immune cells in human tumors raises a fundamental question in oncology: How do cancer cells avoid the destruction by immune attack? In principle, tumor development can be controlled by cytotoxic innate and adaptive immune cells; however, as the tumor develops from neoplastic tissue to clinically detectable tumors, cancer cells evolve different mechanisms that mimic peripheral immune tolerance in order to avoid tumoricidal attack. Here, we provide an update of recent accomplishments, unifying concepts, and future challenges to study tumor-associated immune cells, with an emphasis on metastatic carcinomas. |
| Author | Werb, Zena Hagerling, Catharina Gonzalez, Hugo |
| AuthorAffiliation | Department of Anatomy, the Helen Diller Family Comprehensive Cancer Center, University of California at San Francisco, San Francisco, California 94143, USA |
| AuthorAffiliation_xml | – name: Department of Anatomy, the Helen Diller Family Comprehensive Cancer Center, University of California at San Francisco, San Francisco, California 94143, USA |
| Author_xml | – sequence: 1 givenname: Hugo surname: Gonzalez fullname: Gonzalez, Hugo – sequence: 2 givenname: Catharina surname: Hagerling fullname: Hagerling, Catharina – sequence: 3 givenname: Zena orcidid: 0000-0002-6525-3872 surname: Werb fullname: Werb, Zena |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30275043$$D View this record in MEDLINE/PubMed https://www.osti.gov/servlets/purl/1560566$$D View this record in Osti.gov |
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| Keywords | disseminated tumor cells immune cross-talk patient-derived xenograft cancer heterogeneity metastasis-associated immune cells tumor-associated macrophages |
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| Snippet | The presence of inflammatory immune cells in human tumors raises a fundamental question in oncology: How do cancer cells avoid the destruction by immune... In this review, Gonzelez et al. provide an update of recent accomplishments, unifying concepts, and futures challenges to study tumor-associated immune cells,... |
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| SubjectTerms | B-Lymphocytes - immunology BASIC BIOLOGICAL SCIENCES cancer heterogeneity Carcinoma - immunology Carcinoma - secondary Dendritic Cells - immunology Disease Progression disseminated tumor cells Humans immune cross-talk Immunologic Surveillance Inflammation - immunology Killer Cells, Natural - immunology Macrophages - immunology metastasis-associated immune cells Neoplasm Metastasis - immunology Neoplasms - immunology Neutrophils - immunology patient-derived xenograft Review T-Lymphocytes - immunology tumor-associated macrophages |
| Title | Roles of the immune system in cancer: from tumor initiation to metastatic progression |
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