Effects of diacylglycerol O-acyltransferase 1 (DGAT1) on endoplasmic reticulum stress and inflammatory responses in adipose tissue of ketotic dairy cows

• Published in: Journal of dairy science Vol. 105; no. 11; pp. 9191 - 9205
• Main Authors: Xu, Qiushi, Fan, Yunhui, Loor, Juan J., Jiang, Qianming, Zheng, Xidan, Wang, Zhijie, Yang, Tong, Sun, Xudong, Jia, Hongdou, Li, Xinwei, Xu, Chuang
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.11.2022; Elsevier
• Subjects: 3-Hydroxybutyric Acid; Adenoviridae; adipocytes; adipose tissue; Adipose Tissue - metabolism; Animals; blood serum; bovine adipocytes; Cattle; culture media; Cytokines - metabolism; dairy science; DGAT1; diacylglycerol acyltransferase; Diacylglycerol O-Acyltransferase - metabolism; endoplasmic reticulum; Endoplasmic Reticulum Stress; epinephrine; Epinephrine - pharmacology; Female; Heat-Shock Proteins - metabolism; inflammation; Inflammation - metabolism; Inflammation - veterinary; inflammatory response; Inositol - metabolism; Inositol - pharmacology; interleukin-6; Interleukin-6 - metabolism; JNK Mitogen-Activated Protein Kinases - metabolism; Ketoses - metabolism; Ketoses - pharmacology; ketosis; Ketosis - veterinary; lipolysis; Mice; mitogen-activated protein kinase; monogastric livestock; NF-kappa B - metabolism; NF-KappaB Inhibitor alpha - metabolism; Protein Serine-Threonine Kinases; RNA; RNA, Messenger - metabolism; RNA, Small Interfering - metabolism; secretion; Tumor Necrosis Factor-alpha - metabolism; inflammatory response; DGAT1; bovine adipocytes; endoplasmic reticulum stress

Adipose tissue of ketotic dairy cows exhibits greater lipolytic rate and signs of inflammation, which further aggravate the metabolic disorder. In nonruminants, the endoplasmic reticulum (ER) is a key organelle coordinating metabolic adaptations and cellular functions; thus, disturbances known as ER...