miR-7 and miR-218 epigenetically control tumor suppressor genes RASSF1A and Claudin-6 by targeting HoxB3 in breast cancer

• Published in: Biochemical and biophysical research communications Vol. 424; no. 1; pp. 28 - 33
• Main Authors: Li, Qiaoyan, Zhu, Fufan, Chen, Puxiang
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 20.07.2012
• Subjects: 3' Untranslated Regions - genetics; 60 APPLIED LIFE SCIENCES; abnormal development; breast neoplasms; Breast Neoplasms - genetics; Breast Neoplasms - pathology; CELL CYCLE; Cell Line, Tumor; CELL PROLIFERATION; Claudins - genetics; DNA; DNA methylation; Epigenesis, Genetic; epigenetics; Gene Expression Regulation, Neoplastic; gene overexpression; Histone modification; HISTONES; Homeodomain Proteins - antagonists & inhibitors; Homeodomain Proteins - genetics; homeotic genes; HoxB3; Humans; INHIBITION; MAMMARY GLANDS; MESSENGER-RNA; METHYLATION; microRNA; microRNA-218; microRNA-7; MicroRNAs - genetics; MicroRNAs - metabolism; neoplasm cells; NEOPLASMS; ONCOGENES; post-translational modification; tumor suppressor genes; Tumor Suppressor Proteins - genetics; HoxB3; microRNA-7; microRNA-218; DNA methylation; Histone modification

► Both miR-7 and miR-218 down-regulates HoxB3 expression by targeting the 3′-UTR of HoxB3 mRNA. ► A reverse correlation between the levels of endogenous miR-7, miR218 and HoxB3 expression. ► Epigenetic changes involve in the reactivation of HoxB3. ► Both miRNAs inhibits the cell cycle and clone form...