Cgnz1 allele confers kidney resistance to damage preventing progression of immune complex–mediated acute lupus glomerulonephritis

• Published in: The Journal of experimental medicine Vol. 210; no. 11; pp. 2387 - 2401
• Main Authors: Ge, Yan, Jiang, Chao, Sung, Sun-Sang J., Bagavant, Harini, Dai, Chao, Wang, Hongyang, Kannapell, Carol C., Cathro, Helen P., Gaskin, Felicia, Man Fu, Shu
• Format: Journal Article
• Language: English
• Published: United States The Rockefeller University Press 21.10.2013
• Subjects: Acute Disease; Alleles; Animals; Antigen-Antibody Complex - adverse effects; Autoantibodies - adverse effects; Capillaries - pathology; Capillaries - ultrastructure; Chromosomes, Mammalian - genetics; Dendritic Cells - metabolism; Dendritic Cells - pathology; Disease Progression; Disease Susceptibility; Endocytosis; Endothelial Cells - pathology; Endothelial Cells - ultrastructure; Female; Gene Expression Regulation; Humans; Immunity - immunology; Inflammation - immunology; Inflammation - pathology; Kidney - blood supply; Kidney - immunology; Kidney - pathology; Kidney - ultrastructure; Lupus Nephritis - immunology; Lupus Nephritis - pathology; Macrophages - metabolism; Macrophages - pathology; Mice; Mice, Inbred Strains; Proteins - metabolism; Proteinuria - metabolism; Proteinuria - pathology; Sheep; Vacuoles - pathology; Vacuoles - ultrastructure

Cgnz1 and Agnz1 on the distal region of mouse chromosome 1 are associated with chronic glomerulonephritis (cGN) and acute GN (aGN). NZM2328.Lc1R27 (R27) was generated by introgressing a C57L/J region where Cgnz1 is located to NZM2328. R27 female mice developed aGN mediated by immune complex (IC) dep...