Integrative DNA Methylation and Gene Expression Analysis in the Prefrontal Cortex of Mexicans Who Died by Suicide

• Published in: The international journal of neuropsychopharmacology Vol. 24; no. 12; pp. 935 - 947
• Main Authors: Romero-Pimentel, Ana L, Almeida, Daniel, Muñoz-Montero, Said, Rangel, Claudia, Mendoza-Morales, Roberto, Gonzalez-Saenz, Eli E, Nagy, Corina, Chen, Gary, Aouabed, Zahia, Theroux, Jean-Francois, Turecki, Gustavo, Martinez-Levy, Gabriela, Walss-Bass, Consuelo, Monroy-Jaramillo, Nancy, Fernández-Figueroa, Edith A, Gómez-Cotero, Amalia, García-Dolores, Fernando, Morales-Marin, Mirna E, Nicolini, Humberto
• Format: Journal Article
• Language: English
• Published: US Oxford University Press 01.12.2021
• Subjects: Adult; Analysis; Case-Control Studies; Death of; Demographic aspects; DNA Methylation; Epigenesis, Genetic; Gene Expression; Genetic aspects; Humans; Male; Methylation; Mexicans; Mexico; Physiological aspects; Prefrontal cortex; Prefrontal Cortex - metabolism; Psychological aspects; Regular s; Risk factors; Suicide; Mexico; Mexico; Epigenomics/transcriptomics; postmortem human brain; suicide

Abstract Background Suicide represents a major health concern, especially in developing countries. While many demographic risk factors have been proposed, the underlying molecular pathology of suicide remains poorly understood. A body of evidence suggests that aberrant DNA methylation and expression...