Integrative approaches to treating pain in sickle cell disease: Pre-clinical and clinical evidence
•Pain is a major comorbidity of sickle cell disease with many patients suffering from both acute and chronic pain.•Mechanisms of pain in sickle cell disease are complex with contributions from the central and peripheral nervous systems.•Integrative approaches for treating pain in sickle cell disease...
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Published in | Complementary therapies in medicine Vol. 51; p. 102394 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
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Elsevier Ltd
01.06.2020
Elsevier Limited |
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Abstract | •Pain is a major comorbidity of sickle cell disease with many patients suffering from both acute and chronic pain.•Mechanisms of pain in sickle cell disease are complex with contributions from the central and peripheral nervous systems.•Integrative approaches for treating pain in sickle cell disease are being explored in pre-clinical and clinical studies.
Sickle cell disease (SCD) is a genetic disorder characterized by hemolysis, end-organ damage, inflammation, and pain. Recurrent and unpredictable episodes of acute pain due to vaso-occlusive crises are a unique feature of SCD. Many patients also develop lifelong chronic pain. Opioids are the primary method of pain treatment in SCD; however, continued use is associated with several adverse effects. Integrative approaches to treating pain in SCD are increasingly being explored to prevent the side effects associated with opioids. In this review, we highlight the mechanisms of pain in SCD and describe mechanism-based integrative approaches for treating pain. |
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AbstractList | Sickle cell disease (SCD) is a genetic disorder characterized by hemolysis, end-organ damage, inflammation, and pain. Recurrent and unpredictable episodes of acute pain due to vaso-occlusive crises are a unique feature of SCD. Many patients also develop lifelong chronic pain. Opioids are the primary method of pain treatment in SCD; however, continued use is associated with several adverse effects. Integrative approaches to treating pain in SCD are increasingly being explored to prevent the side effects associated with opioids. In this review, we highlight the mechanisms of pain in SCD and describe mechanism-based integrative approaches for treating pain. •Pain is a major comorbidity of sickle cell disease with many patients suffering from both acute and chronic pain.•Mechanisms of pain in sickle cell disease are complex with contributions from the central and peripheral nervous systems.•Integrative approaches for treating pain in sickle cell disease are being explored in pre-clinical and clinical studies. Sickle cell disease (SCD) is a genetic disorder characterized by hemolysis, end-organ damage, inflammation, and pain. Recurrent and unpredictable episodes of acute pain due to vaso-occlusive crises are a unique feature of SCD. Many patients also develop lifelong chronic pain. Opioids are the primary method of pain treatment in SCD; however, continued use is associated with several adverse effects. Integrative approaches to treating pain in SCD are increasingly being explored to prevent the side effects associated with opioids. In this review, we highlight the mechanisms of pain in SCD and describe mechanism-based integrative approaches for treating pain. |
ArticleNumber | 102394 |
Author | Sagi, Varun Kiven, Stacy Gupta, Kalpna Argueta, Donovan A |
AuthorAffiliation | 1 Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, MN 2 Hematology/Oncology, Department of Medicine, University of California, Irvine and Southern California Institute for Research and Education, VA Medical Center, Long Beach, CA |
AuthorAffiliation_xml | – name: 2 Hematology/Oncology, Department of Medicine, University of California, Irvine and Southern California Institute for Research and Education, VA Medical Center, Long Beach, CA – name: 1 Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, MN |
Author_xml | – sequence: 1 givenname: Varun surname: Sagi fullname: Sagi, Varun organization: Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, MN, United States – sequence: 2 givenname: Donovan A surname: Argueta fullname: Argueta, Donovan A organization: Hematology/Oncology, Department of Medicine, University of California, Irvine and Southern California Institute for Research and Education, VA Medical Center, Long Beach, CA, United States – sequence: 3 givenname: Stacy surname: Kiven fullname: Kiven, Stacy organization: Hematology/Oncology, Department of Medicine, University of California, Irvine and Southern California Institute for Research and Education, VA Medical Center, Long Beach, CA, United States – sequence: 4 givenname: Kalpna surname: Gupta fullname: Gupta, Kalpna email: kalpnag@hs.uci.edu, kalpnag@uci.edu organization: Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, MN, United States |
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Keywords | Sickle cell disease Pain |
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Snippet | •Pain is a major comorbidity of sickle cell disease with many patients suffering from both acute and chronic pain.•Mechanisms of pain in sickle cell disease... Sickle cell disease (SCD) is a genetic disorder characterized by hemolysis, end-organ damage, inflammation, and pain. Recurrent and unpredictable episodes of... |
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SubjectTerms | Acupuncture Analgesics Anemia, Sickle Cell - therapy Animals Bioavailability Chronic pain Chronic Pain - therapy Clinical trials Cytokines Diet Dietary supplements Endothelium Fatty acids Genetic disorders Hemoglobin Humans Inflammation Kinases Mice Narcotics Nervous system Opioids Oxidative stress Pain Pain Management - methods Pediatrics Proteins Sickle cell disease Side effects Spinal cord Tumor necrosis factor-TNF |
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Title | Integrative approaches to treating pain in sickle cell disease: Pre-clinical and clinical evidence |
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