Combined Salivary Proteome Profiling and Machine Learning Analysis Provides Insight into Molecular Signature for Autoimmune Liver Diseases Classification

• Published in: International journal of molecular sciences Vol. 24; no. 15; p. 12207
• Main Authors: Guadalupi, Giulia, Contini, Cristina, Iavarone, Federica, Castagnola, Massimo, Messana, Irene, Faa, Gavino, Onali, Simona, Chessa, Luchino, Vitorino, Rui, Amado, Francisco, Diaz, Giacomo, Manconi, Barbara, Cabras, Tiziana, Olianas, Alessandra
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 30.07.2023; MDPI
• Subjects: Acids; Antibodies; Antigens; Autoimmune Diseases; Bile ducts; Biopsy; Cholangitis; Comparative analysis; Exocrine glands; Hepatitis, Autoimmune; Humans; Immune system; Ions; Liver cirrhosis; Liver Cirrhosis, Biliary; Liver Diseases; Machine learning; Males; Mass spectrometry; Medical research; Medicine, Experimental; Peptides; Proteins; Proteome; Proteomics; Rheumatoid arthritis; Scientific equipment and supplies industry; Scientific imaging; Smooth muscle; Somatotropin; United States; saliva; Cofilin-1; hornerin; autoimmune hepatitis; autoimmune liver diseases; bottom-up proteomics; mass spectrometry; random forest; primary biliary cholangitis

Autoimmune hepatitis (AIH) and primary biliary cholangitis (PBC) are autoimmune liver diseases that target the liver and have a wide spectrum of presentation. A global overview of quantitative variations on the salivary proteome in presence of these two pathologies is investigated in this study. The...